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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

ABSTRACT: Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

PROVIDER: PRJNA983290 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24907485_1.fastq.gz	Fastqsanger.gz
	SRR24907485_2.fastq.gz	Fastqsanger.gz
	SRR24907486_1.fastq.gz	Fastqsanger.gz
	SRR24907486_2.fastq.gz	Fastqsanger.gz
	SRR24907487_1.fastq.gz	Fastqsanger.gz

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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

| PRJNA1137400 | ENA

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

| PRJNA983299 | ENA

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

| PRJNA983297 | ENA

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

Project description:The list of circular RNAs (circRNAs) involved in tumor metabolic reprogramming is rapidly increasing, but whether circRNAs have a role in linking epigenetic modification with lipid metabolism remains elusive. Here, we demonstrate that the circRNA circEPB41(2), which expression is driven by HNRNPA1 in response to glucose deprivation, is important for de novo lipogenesis. Moreover, we uncovered a genome-wide decrease in specific histone acetylation after circEPB41(2) depletion. These changes are associated with altered gene expression and observed cellular phenotypes, suggesting their functional significance. Mechanistically, we showed that circEPB41(2) regulates histone acetylation in part by modulating the stability and polyadenylation of SIRT6 through binding and maintaining the demethylase activity of FTO. Accordingly, circEPB41(2) silencing inhibited cellular lipid accumulation, suppressed cell proliferation, and inhibited cancer xenograft growth. Thus, circEPB41(2) may consider a target for cancer treatment.

2024-07-25 | GSE272595 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

2023-10-11 | GSE234823 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

2023-10-11 | GSE234822 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-11 | GSE234825 | GEO

Histone modifications in lung epithelial cells

Project description:Histone modifications in lung epithelial cells

| PRJNA594274 | ENA

Time makes histone H3 modifications drift

Project description:Time makes histone H3 modifications drift

| PRJNA742128 | ENA

VRK1 regulates sensitivity to oxidative stress by altering the nuclear phosphoproteome and histone epigenetic modifications

Project description:Chromatin organization and its dynamic remodeling determine its accessibility and sensitivity to DNA damage. The major source of endogenous DNA damage is oxidative stress. We studied the role of the VRK1 chromatin kinase in the response to oxidative stress, which alters the nuclear phosphoproteome and the histone epigenetic pattern. Oxidative stress causes an accumulation of 8-oxoG DNA lesions that were significantly increased by VRK1 depletion, causing a significant accumulation of DNA strand breaks detected by their labeling with TUNEL assays. The analysis of the nuclear phosphoproteome in response to oxidative stress detected an enrichment of phosphorylated proteins associated with chromosome organization and chromatin remodeling, and these protein phosphorylations significantly decreased after VRK1 depletion. Because chromatin remodeling requires covalent modifications in the histone tails, we studied the effect of oxidative stress on the pattern of histones H4 and H3 epigenetic modifications. Oxidative stress induced the acetylation of H4 in K16, an increase of H3K9 acetylation, and a loss of H3K4me3. Depletion of VRK1 altered all these modifications induced by oxidative stress and resulted in the loss of H4K16ac and H3K9ac and an increase in H3K9me3 and H3K4me3 levels. All these changes induced by oxidative stress in the epigenetic pattern of histones are impaired by the depletion of VRK1, indicating that VRK1 plays a major role in the functional reorganization of chromatin in the response to oxidative stress. VRK1 depletion alters the nuclear phosphoproteome and the histone epigenetic pattern in response to oxidative stress.

2024-05-24 | PXD040944 | Pride

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