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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

ABSTRACT: Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

PROVIDER: PRJNA983297 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24910198_1.fastq.gz	Fastqsanger.gz
	SRR24910198_2.fastq.gz	Fastqsanger.gz
	SRR24910199_1.fastq.gz	Fastqsanger.gz
	SRR24910199_2.fastq.gz	Fastqsanger.gz
	SRR29885562_1.fastq.gz	Fastqsanger.gz

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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

| PRJNA983290 | ENA

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

Project description:Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [H3K9ac ChIP-seq]

Project description:The list of circular RNAs (circRNAs) involved in tumor metabolic reprogramming is rapidly increasing, but whether circRNAs have a role in linking epigenetic modification with lipid metabolism remains elusive. Here, we demonstrate that the circRNA circEPB41(2), which expression is driven by HNRNPA1 in response to glucose deprivation, is important for de novo lipogenesis. Moreover, we uncovered a genome-wide decrease in specific histone acetylation after circEPB41(2) depletion. These changes are associated with altered gene expression and observed cellular phenotypes, suggesting their functional significance. Mechanistically, we showed that circEPB41(2) regulates histone acetylation in part by modulating the stability and polyadenylation of SIRT6 through binding and maintaining the demethylase activity of FTO. Accordingly, circEPB41(2) silencing inhibited cellular lipid accumulation, suppressed cell proliferation, and inhibited cancer xenograft growth. Thus, circEPB41(2) may consider a target for cancer treatment.

2023-10-11 | GSE234822 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [ncRNA-seq]

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Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications [RNA-seq]

2023-10-11 | GSE234823 | GEO

Energy stress-induced circEPB41(2) regulates lipogenesis through histone modifications

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-11 | GSE234825 | GEO

Chromatin immunoprecipitation to identify histone modifications (H3K9me3, H3K9Ac, H3K4me3, H4K20me3) in Plasmodium falciparum wild type and Sir2 knock-outs

Project description:Histone modifications (H3K9me3, H3K9Ac, H3K4me3, H4K20me3) across Plasmodium falciparum genome in 3D7 wt and 3D7 Sir2 KO

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A Genome-wide Chronological Study of Gene Expression and Two Histone Modifications, H3K4me3 and H3K9ac, during Developmental Leaf Senescence [ChIP-seq]

Project description:The genome-wide abundance of two histone modifications, H3K4me3 and H3K9ac, both associated with actively expressed genes, was monitored in Arabidopsis thaliana leaves at different time points during developmental senescence, along with expression in the form of RNA-seq data. H3K9ac and H3K4me3 marks were highly convergent at all stages of leaf aging, but H3K4me3 marks covered nearly twice the gene area as H3K9ac marks. Genes with the greatest fold-change in expression displayed the largest positively-correlated percent change in coverage for both marks. Most senescence up-regulated genes were pre-marked by H3K4me3 and H3K9ac, but at levels below the whole-genome average, and for these genes, gene expression increased without a significant increase in either histone mark. However, for a subset of genes showing increased or decreased expression, the respective gain or loss of H3K4me3 marks were found to closely match the temporal changes in mRNA abundance. 22% of genes that increased expression during senescence showed accompanying changes in H3K4me3 modification, and they include numerous regulatory genes, which may act as primary response genes. H3K4me3 and H3K9ac were measured on a genome-wide scale using ChIP-seq at different stages of leaf aging.

2015-04-11 | E-GEOD-67776 | biostudies-arrayexpress

A Genome-wide Chronological Study of Gene Expression and Two Histone Modifications, H3K4me3 and H3K9ac, during Developmental Leaf Senescence [RNA-seq]

2015-04-11 | E-GEOD-67777 | biostudies-arrayexpress