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ABSTRACT: CYST

PROVIDER: PRJNA1179718 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR31161100.fastq.gz	Fastqsanger.gz
	SRR31161101.fastq.gz	Fastqsanger.gz
	SRR31161102.fastq.gz	Fastqsanger.gz
	SRR31161103.fastq.gz	Fastqsanger.gz
	SRR31161104.fastq.gz	Fastqsanger.gz

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Project description:OBJECTIVE: Due to the common occurrence of peritumoral cysts throughout the central nervous system tumors, hemangioblastomas (HBs) provide a model of cyst to further study the molecular mechanisms of peritumoral cyst formation. METHODS: We conducted an integrated lipidomics and transcriptomics analysis on solid and cyst HB samples, to elucidate the changes in lipid profile and the expression levels of genes associated with lipid metabolism in the cyst formation. RESULTS: Transcriptomic analysis revealed differentially expressed genes between the solid and cystic HBs. The lipidomic analysis further showed a significant reduction in the abundance of triacylglycerol, ceramide, lysophosphatidylcholine, and lysophosphatidylethanolamine, and an increase in phosphatidylcholine and phosphatidylethanolamine in the cystic group. Besides, bioinformatics analysis revealed altered lipid biosynthesis, glycerophospholipid metabolism and phospholipase activity in the cyst HBs. CONCLUSION: Our findings indicate that aberrant lipid metabolism is a causative factor of cyst formation in HBs, and provide novel insights into the role of lipid metabolism in HBs.

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Confirmation of the gene expression pattern in Mxi1-deficient mouse

Project description:For final aim to completes network map between gene that is concerned in cystogenesis, verifies meaning genes connected with cyst formation analyzing gene pattern in Mxi1 KO mouse that have phenotype of polycystic kidney disease. Monitoring meaning genes through microarray analysis, and confirm the function of these genes. Also, find pathway including meaning genes and new pathway related with PKD. Completes network map concerned in cystogenesis through integrates knowing pathway and predicting pathway. Develope diagnostic of cyst disease and cure target through such completed network map, and wish to clear new role of cyst formation connection gene through in vivo model and examine closely control system of cyst formation mechanism. Keywords: Cystogenesis Use 1 mouse at each experiment and control. Indirect labeling of 10g cRNA, using bacterial control mRNA.

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