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TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [scRNA-Seq]

ABSTRACT: TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [scRNA-Seq]

PROVIDER: PRJNA1179888 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31162356_1.fastq.gz	Fastqsanger.gz
	SRR31162356_2.fastq.gz	Fastqsanger.gz
	SRR31162378_1.fastq.gz	Fastqsanger.gz
	SRR31162378_2.fastq.gz	Fastqsanger.gz

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TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [bulkRNA-seq]

Project description:TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [bulkRNA-seq]

| PRJNA1179315 | ENA

TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [10 Visium Spatial Seq]

Project description:TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [10 Visium Spatial Seq]

| PRJNA1179316 | ENA

TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [bulkRNA-seq]

Project description:Analysis of single cell RNA-seq, CITE-seq data and bulk RNA-seq data on cells isolated from the livers of mice following PBS and APAP (paracetamol/acetaminophen) administration. Spatial Transcriptomics analysis was performed using 10x Visium platform on mouse livers 48hrs post PBS or APAP administration. We also analysed single cell RNA-seq data on CD64+F4/80+ macrophages isolated from the livers of Trem2 fl/fl mice and CD64CRE Trem2 fl/fl mice.

2024-10-30 | GSE280514 | GEO

TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [scRNA-Seq]

2024-10-30 | GSE280652 | GEO

TREM2 expression delineates spatially restricted and ontogenically distinct hepatic macrophages populations required for tissue repair. [10 Visium Spatial Seq]

2024-10-30 | GSE280515 | GEO

Spatially restricted immune and microbiota-driven adaptation of the gut

Project description:Spatially restricted immune and microbiota-driven adaptation of the gut

| PRJNA1027812 | ENA

TREM2 regulates microglial cell activation in response to demyelination in vivo

Project description:Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in humans cause presenile dementia, while genetic variants are associated with increased risk of neurodegenerative diseases. In myeloid cells, TREM2 has been involved in the regulation of phagocytosis, cell proliferation and inflammatory responses in vitro. However, it is unknown how TREM2 contributes to microglia function in vivo. Here, we identify a critical role for TREM2 in the activation and function of microglia during cuprizone (CPZ)-induced demyelination. TREM2-deficient (TREM2(-/-)) mice had defective clearance of myelin debris and more axonal pathology, resulting in impaired clinical performances compared to wild-type (WT) mice. TREM2(-/-) microglia proliferated less in areas of demyelination and were less activated, displaying a more resting morphology and decreased expression of the activation markers MHC II and inducible nitric oxide synthase as compared to WT. Mechanistically, gene expression and ultrastructural analysis of microglia suggested a defect in myelin degradation and phagosome processing during CPZ intoxication in TREM2(-/-) microglia. These findings place TREM2 as a key regulator of microglia activation in vivo in response to tissue damage. Two STAGE (6weeks 12 weeks),

2015-07-06 | E-GEOD-70475 | biostudies-arrayexpress

Spatially restricted immune and microbiota-driven adaptation of the gut [Spatial Transcriptomics]

Project description:Spatially restricted immune and microbiota-driven adaptation of the gut [Spatial Transcriptomics]

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Spatially restricted immune and microbiota-driven adaptation of the gut [scRNA-seq]

Project description:Spatially restricted immune and microbiota-driven adaptation of the gut [scRNA-seq]

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TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Project description:Triggering receptor expressed on myeloid cell 2 (TREM2) is linked to neurodegenerative disease risk. However, the function of TREM in neurodegeneration is still unclear. Here we investigated the role of microglial TREM2 in TAR-DNA binding protein 43 kDa (TDP-43)-related neurodegeneration using viral-mediated and transgenic mouse models. We found that TREM2 deficiency impaired phagocytic clearance of pathological TDP-43 by microglia, and enhanced neuronal damage and motor impairments. Mass cytometry analysis revealed that hTDP-43 induced a TREM2-dependent subpopulation of microglia with high CD11c expression and phagocytic ability. Using mass spectrometry and surface plasmon resonance analysis, we further demonstrated an interaction between TDP-43 and TREM2 in vitro and in vivo as well as in ALS patient tissues. We computationally identified the region within hTDP-43 that interacts with TREM2. Our data highlights that TDP-43 is a possible ligand for microglial TREM2 and that this interaction mediates neuroprotection effects of microglia in TDP-43-related neurodegeneration.

2022-08-12 | PXD029429 | Pride

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