Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Severe Fever with Thrombocytopenia Syndrome virus sequencing method

PROVIDER: PRJNA1196848 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31677551_1.fastq.gz	Fastqsanger.gz
	SRR31677552_1.fastq.gz	Fastqsanger.gz
	SRR31677553_1.fastq.gz	Fastqsanger.gz
	SRR31677554_1.fastq.gz	Fastqsanger.gz
	SRR31677555_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Quantitative proteomic analysis of SFTSV infected THP-1 cells

Project description:Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus causing a high fatality of 12-50% in infected patients. In-depth understanding of the SFTSV induced pathogenesis mechanism is critical for developing effective anti-SFTS therapeutics.

2022-09-05 | PXD017224 | Pride

Severe fever with thrombocytopenia syndrome virus

Project description:Severe fever with thrombocytopenia syndrome virus Genome sequencing and assembly

| PRJNA1065814 | ENA

Severe fever with thrombocytopenia syndrome virus

Project description:Severe fever with thrombocytopenia syndrome virus Raw sequence reads

| PRJNA732992 | ENA

Project description:Research of Severe fever with thrombocytopenia syndrome

| PRJNA1056662 | ENA

Severe fever with thrombocytopenia syndrome virus

Project description:Research of Severe fever with thrombocytopenia syndrome

| PRJNA1056441 | ENA

Serum Proteomics of Severe Fever with Thrombocytopenia Syndrome Patients

Project description:Dabie bandavirus, also termed as severe fever with thrombocytopenia syndrome virus (SFTSV), was first isolated in China in 2010. At this time, the virus was found to have spread to South Korea, Japan, and other countries. A high case fatality rate is reported for SFTS, ranging from 12–50% within various sources. Several omics for clinical studies among SFTS patients as well as studies of cultured SFTSV have attempted to characterize the relevant molecular biology and epidemiology of the disease. However, a global serum proteomics analysis among SFTS patients has not yet been reported to date. Thrombocytopenia and multiple organ failure are the major immediate causes of death among SFTS patients. In this study, serum proteomic changes related to thrombocytopenia, abnormal immune response, and inflammatory activation were documented in SFTS patients. These findings provide useful information forunderstanding the clinical manifestations of SFTS.

2022-10-13 | PXD033989 | Pride

Expression profile and clinical significance of miRNAs at different stages of severe fever with thrombocytopenia syndrome (SFTS) in Chinese patients

Project description:In order to determine the microRNAs profile in peripheral blood mononuclear cell (PBMC) from severe febrile with thrombocytopenia syndrome virus infection and investigate possible diagnostic value of these differential microRNAs.

2023-05-01 | GSE130933 | GEO

Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

Project description:Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the WHO most dangerous pathogens, has 12-30% fatality rates with a characteristic thrombocytopenia syndrome. With a majority of clinically diagnosed SFTSV patients older than ~50 years, age is a critical risk factor for SFTSV morbidity and mortality. Here, we report an age-dependent ferret model of SFTSV infection and pathogenesis that fully recapitulates the clinical manifestations of human infections. While young adult ferrets (≤2 years old) did not show any clinical symptoms and mortality, SFTSV-infected aged ferrets (≥4 years old) demonstrated severe thrombocytopenia, reduced white blood cells, and high fever with 93% mortality rate. Moreover, significantly higher viral load was observed in aged ferrets. Transcriptome analysis of SFTSV-infected young ferrets revealed strong interferon-mediated anti-viral signaling, whereas inflammatory immune responses were markedly upregulated and persisted in aged ferrets. Thus, this immunocompetent age-dependent ferret model should be useful for anti-SFTSV therapy and vaccine development.

2018-10-30 | GSE121911 | GEO

Transcriptome profiles characteristics of peripheral immune in Severe Fever with Thrombocytopenia Syndrome patients

Project description:To investigate the response mechanisms of Severe fever with thrombocytopenia syndrome (SFTS) patients, we conducted transcriptomic analysis of peripheral immunity in 14 SFTS patients, ranging from modal infection to severe and fatal disease. Our results observed the potential mechanism for the heterogeneity of clinical symptoms, which can further elucidate the interaction between viruses and hosts and contribute to clinical treatment.

2024-11-20 | GSE264635 | GEO

Analysis of SFTS pathogenesis based on single-cell RNA sequencing of monocytes

Project description:Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified tick-borne viral disease with a high mortality rate. Monocytes are known to play an important role in the pathogenesis of SFTS, but the distinct subpopulations of monocytes associated with the disease progression and their roles in inflammatory responses remain poorly elucidated. In this study, we used single-cell RNA sequencing (scRNA-seq) to explore the specific monocyte subpopulations correlated with the progression of SFTS and their involvement in inflammatory processes.

2025-01-27 | GSE287827 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data