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Homo sapiens

ABSTRACT: Gene expression signatures of symptomatic respiratory viral infection in adults

OTHER RELATED OMICS DATASETS IN: E-GEOD-17156

PROVIDER: PRJNA119759 | ENA |

REPOSITORIES: ENA

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E-GEOD-17156

Project description:Gene expression signatures of symptomatic respiratory viral infection in adults

2015-08-12 | E-GEOD-17156 | ExpressionAtlas

RNAseq of nasal cells from pre-symptomatic volunteers experimentally infected with RSV

Project description:We report the analysis of nasal curettage cells by RNAseq collected at pre-symptomatic timepoints in healthy adults experimentally challenged with respiratory syncytial virus (RSV). Following inoculation, 57% of participants developed PCR-confirmed infection. Prior to viral challenge, 80 differentially expressed genes were identified that associated with susceptibility to symptomatic infection. At day 3, 87 differentially expressed genes were associated with protection. Thus, we showed that the nasal mucosa at the time of virus exposure and during the incubation phase correlate with susceptibiltiy and protection from respiratory viral infection.

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Gene expression signatures of symptomatic respiratory viral infection in adults

Project description:Diagnosis of acute respiratory viral infection is currentlybased on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis. We used microarrays to capture peripheral blood gene expression at baseline and time of peak symptoms in healthy volunteers infected intranasally with influenza A H3N2, respiratory syncytial virus or rhinovirus. We determined groups of coexpressed genes that accurately classified symptomatic versus asymptomatic individuals.

2009-08-06 | GSE17156 | GEO

Gene expression signatures of symptomatic respiratory viral infection in adults

Project description:Diagnosis of acute respiratory viral infection is currently based on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis. We used microarrays to capture peripheral blood gene expression at baseline and time of peak symptoms in healthy volunteers infected intranasally with influenza A H3N2, respiratory syncytial virus or rhinovirus. We determined groups of coexpressed genes that accurately classified symptomatic versus asymptomatic individuals. We experimentally inoculated healthy volunteers with intranasal influenza, respiratory syncytial virus or rhinovirus. Symptoms were documented and peripheral blood samples drawn into PAXgene tubes for RNA isolation.

2009-08-06 | E-GEOD-17156 | biostudies-arrayexpress

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Project description:Acute Viral Respiratory Infection Genetics

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