Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Digital gene and expression profiling of primary acute lymphoblastic leukemia (ALL) cells

PROVIDER: PRJNA136119 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR091652.fastq.gz	Fastqsanger.gz
	SRR091653.fastq.gz	Fastqsanger.gz
	SRR091654.fastq.gz	Fastqsanger.gz
	SRR091655.fastq.gz	Fastqsanger.gz
	SRR091656.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Digital gene and expression profiling of primary acute lymphoblastic leukemia (ALL) cells

Project description:This SuperSeries is composed of the following subset Series: GSE26530: Digital gene expression profiling of primary acute lymphoblastic leukemia cells GSE26865: Gene expression profiling of primary acute lymphoblastic leukemia (ALL) cells Refer to individual Series

2011-12-20 | E-GEOD-26878 | biostudies-arrayexpress

Homo sapiens

Project description:Digital gene expression profiling of primary acute lymphoblastic leukemia cells

| PRJNA142169 | ENA

Homo sapiens

Project description:Gene expression profiling of primary acute lymphoblastic leukemia (ALL) cells

| PRJNA142009 | ENA

Digital gene expression profiling of primary acute lymphoblastic leukemia cells

Project description:We determined the genome-wide digital gene expression (DGE) profiles of primary acute lymphoblastic leukemia (ALL) cells from 28 patients and fractionated blood cells from healthy blood donors taking advantage of “second generation” sequencing technology. The patients included in the study represent distinct subtypes of B-cell precursor (BCP) ALL and T-cell lineage ALL (T-ALL) and the controls are fractionated CD19+ and CD3+ cells.

2011-12-20 | GSE26530 | GEO

Transcription profiling of human primary acute lymphoblastic leukemia cells from bone marrow of 161 pediatric associated with methotrexate treatment response

Project description:Genome-wide assessment of gene expression in primary acute lymphoblastic leukemia cells was performed to identify genomic determinants of MTXâs antileukemic effects. Reduction of circulating leukemia cells after in vivo methotrexate treatment served as a measure MTX's antileukemic effects. Experiment Overall Design: Gene expression in diagnostic primary acute lymphoblastic leukemia cells from bone marrow of 161 pediatric patients

2008-04-06 | E-GEOD-10255 | biostudies-arrayexpress

Proteogenomics of High hyperdiploid childhood acute lymphoblastic leukemia

Project description:Proteogenomic analysis and genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of High hyperdiploid childhood acute lymphoblastic leukemia.

2020-01-29 | MSV000084862 | MassIVE

Proteogenomics of High hyperdiploid childhood acute lymphoblastic leukemia

Project description:Proteogenomic analysis and genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of High hyperdiploid childhood acute lymphoblastic leukemia.

2019-02-25 | PXD010175 | Pride

Development of gene expression signatures with lncRNAs for 64 T-ALL patient samples

Project description:Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T-cell acute lymphoblastic leukemias, supporting an essential driver role for this gene in T-cell acute lymphoblastic leukemia oncogenesis. In this study, we aimed to establish a comprehensive compendium of the long non-coding RNA transcriptome under control of Notch signaling. For this purpose, we measured the transcriptional response of all protein coding genes and long non-coding RNAs upon pharmacological Notch inhibition in the human T-cell acute lymphoblastic leukemia cell line CUTLL1 using RNA-sequencing. Similar Notch dependent profiles were established for normal human CD34+ thymic T-cell progenitors exposed to Notch signaling activity in vivo. In addition, we generated long non-coding RNA expression profiles (array data) from GSI treated T-ALL cell lines, ex vivo isolated Notch active CD34+ and Notch inactive CD4+CD8+ thymocytes and from a primary cohort of 15 T-cell acute lymphoblastic leukemia patients with known NOTCH1 mutation status. Integration of these expression datasets with publically available Notch1 ChIP-sequencing data resulted in the identification of long non-coding RNAs directly regulated by Notch activity in normal and malignant T-cell context. Given the central role of Notch in T-cell acute lymphoblastic leukemia oncogenesis, these data pave the way towards development of novel therapeutic strategies that target hyperactive Notch1 signaling in human T-cell acute lymphoblastic leukemia. Gene expression profiling of 64 T-ALL patient samples

2014-10-27 | E-GEOD-61866 | biostudies-arrayexpress

Gene expression in primary acute lymphoblastic leukemia (ALL) associated with methotrexate treatment response

Project description:Genome-wide assessment of gene expression in primary acute lymphoblastic leukemia cells was performed to identify genomic determinants of MTX’s antileukemic effects. Reduction of circulating leukemia cells after in vivo methotrexate treatment served as a measure MTX's antileukemic effects. Keywords: gene expression associated with drug response

2008-03-15 | GSE10255 | GEO

Homo sapiens

Project description:Gene expression profiling of CREB knockdown in Acute Lymphoblastic Leukemia cells

| PRJNA282674 | ENA