Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA137391 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Human samples of various thyroid carcinomas, adenomas, and normals, each from a different patient, had mRNA assays performed using Affymetrix HG_U133A arrays, with 22283 probe-sets. The 99 samples consisted of 4 normals, 10 follicular adenomas, 13 follicular carcinomas, 7 oncocytic adenomas, 8 oncocytic carcinomas, 51 papillary carcinomas (each typed as having classical, follicular or tall cell morphology), 4 anaplastic carcinomas, and 2 medullary carcinomas. Interesting additional information on common mutations are provided including RAS mutation, BRAF mutation, RET/PTC rearrangements, and PAX8/PPARG translocations. Details of those assays are provided in our linked publications, as well as additional details on the specific mutations in a few special cases. No survival data is provided. Information for 93 of the 99 samples was previously made available on the web. The anaplastic and medullary carcinoma data were not previously shared. A supplementary Excel spreadsheet holding the same processed data as the series matrix file is provided and is more compact. The raw (.CEL) files are also provided. Human samples of various thyroid carcinomas, adenomas, and normals. The 99 samples consisted of 4 normals, 10 follicular adenomas, 13 follicular carcinomas, 7 oncocytic adenomas, 8 oncocytic carcinomas, 51 papillary carcinomas (each typed as having classical, follicular or tall cell morphology), 4 anaplastic carcinomas, and 2 medullary carcinomas. Additional information on common mutations are provided including RAS mutation, BRAF mutation, RET/PTC rearrangements, and PAX8/PPARG translocations.
2011-02-09 | E-GEOD-27155 | biostudies-arrayexpress
Project description:Human samples of various thyroid carcinomas, adenomas, and normals, each from a different patient, had mRNA assays performed using Affymetrix HG_U133A arrays, with 22283 probe-sets. The 99 samples consisted of 4 normals, 10 follicular adenomas, 13 follicular carcinomas, 7 oncocytic adenomas, 8 oncocytic carcinomas, 51 papillary carcinomas (each typed as having classical, follicular or tall cell morphology), 4 anaplastic carcinomas, and 2 medullary carcinomas. Interesting additional information on common mutations are provided including RAS mutation, BRAF mutation, RET/PTC rearrangements, and PAX8/PPARG translocations. Details of those assays are provided in our linked publications, as well as additional details on the specific mutations in a few special cases. No survival data is provided. Information for 93 of the 99 samples was previously made available on the web. The anaplastic and medullary carcinoma data were not previously shared. A supplementary Excel spreadsheet holding the same processed data as the series matrix file is provided and is more compact. The raw (.CEL) files are also provided.
2011-02-09 | GSE27155 | GEO
Project description:A two miRNA classifier differentiates follicular thyroid carcinomas from follicular thyroid adenomas
| PRJNA263179 | ENA
Project description:A cohort of distinct thyroid neoplasias was hybridized onto the Affymetrix U95 GeneChip We profiled the gene expression of a cohort of 9 Hurthle cell adenomas, 17 follicular adenomas, 9 follicular thyroid carcinomas, 13 follicular variants of papillary thyroid carcinomas, 6 Hashimoto throiditis, 8 thyroid hyperplasias and 9 papillary thyroid carcinomas.
2012-05-31 | E-GEOD-29315 | biostudies-arrayexpress
Project description:Experiment a) Establishment of expression profiles in conventional papillary thyroid carcinomas (PTCs) with a BRAF mutation vs. PTCs without a BRAF mutation and using normal thyroid (TN) specimens as reference. Experiment b) Establishment of expression profiles in follicular adenomas (FAs) of the thyroid and follicular variant of papillary thyroid carcinomas (FVPTCs).
2015-02-16 | GSE54958 | GEO
Project description:Follicular thyroid tumours were investigated using global gene expression analysis. Aim of this study was the identification of new markers for follicular thyroid carcinoma. Keywords: cell type comparison Gene expression analysis of 4 follicular thyroid adenomas, 4 follicular thyroid carcinomas, and 4 microinvasive follicular thyroid carcinomas.
2009-02-27 | E-GEOD-15045 | biostudies-arrayexpress
Project description:RNA-Sequencing of human papillary thyroid carcinomas
| PRJNA272493 | ENA
Project description:Sixty-nine (69) tumor samples were collected from patients who underwent thyroidectomy.<br><br>The tumors included 22 benign follicular adenomas, 18 follicular carcinomas, 12 samples of microfollicular adenomas, 4 anaplastic carcinomas, 2 papillary carcinomas, and 9 nodular goiters. 23 samples were obtained from the expression profile repository, Array Express, these counted 14 papillary carcinomas and 9 normal thyroid.
2010-08-05 | E-MEXP-2442 | biostudies-arrayexpress
Project description:Study of a series of 23 human thyroid tissues including 11 normal tissue, 4 follicular thyroid adenomas and 8 follicular thyroid carcinomas, in order to identify molecular profile associated with PAX8PPARgamma translocation. The main factor is presence of PAX8PPARgamma translocation. Other clinical factors are also described for each sample. (see supplementary Tables). The reference used is a pool of equal quantities of mRNA from each of the 23 samples studied.
2005-06-28 | E-TABM-11 | biostudies-arrayexpress
Project description:Experiment a) Establishment of expression profiles in conventional papillary thyroid carcinomas (PTCs) with a BRAF mutation vs. PTCs without a BRAF mutation and using normal thyroid (TN) specimens as reference. Experiment b) Establishment of expression profiles in follicular adenomas (FAs) of the thyroid and follicular variant of papillary thyroid carcinomas (FVPTCs). We extracted DNA from specimens and performed mutational analysis in malignant lesions and extracted RNA that was processed and hybridized to Affymetrix microarrays.
2015-02-16 | E-GEOD-54958 | biostudies-arrayexpress