Project description:5′-phosphoribosyl-5-amino-4-imidazole carboxamide monophosphate (ZMP) is a metabolic intermediate of the de novo purine biosynthesis pathway. Its accumulation in several cell types from bacteria to human is associated with growth impairment. Identification of ZMP-binding proteins was performed to understand the molecular basis of ZMP toxicity. To assess the specificity of ZMP-binding proteins, an affinity chromatography approach was also applied to the closely related molecules AMP, SZMP (Succinyl-ZMP) and AICAR (5-amino-4-imidazole carboxamide ribonucleoside, also named Acadesine).

2018-11-21 | PXD007780 | Pride

Saccharomyces cerevisiae

Project description:Analysis of the effect of L-carnitine supplementation on global expression of Sachharomyces cerevisiae cultures

| PRJNA116339 | ENA

Project description:Effect of AICAR monophosphate and AICAr riboside accumulation on global transcription

| PRJNA140119 | ENA

Effect of 5-amino-4-imidazolecarboxamide ribotide (AICAr) supplementation on global transcription

Project description:We investigated the effects of AICAr supplementation on the global transcriptome of Y2950. The Y2950 strain was grown with or without AICAr. For each comparison, we made 2 biological replicates, swapping dyes.

2011-08-31 | E-GEOD-29019 | biostudies-arrayexpress

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