Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA175815 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:To elucidate the mechamisms of colonic Treg cell induction by microbial metabolite(s), chroloform-resistant bacteria (CRB)-associated mice was developed and given low-fiber diet (LFD) and high-fiber diet (HFD). The colonic epithelial cells were isolated and gene expression profiles were analyzed by GeneChip. Clonic epithelial cells in CRB mice fed with HFD and LFD were isolated for RNA extraction and hybridization on Affymetrix microarrays.
2014-08-11 | E-GEOD-41104 | biostudies-arrayexpress
Project description:To elucidate the mechamisms of colonic Treg cell induction by microbial metabolite(s), chroloform-resistant bacteria (CRB)-associated mice was developed and given low-fiber diet (LFD) and high-fiber diet (HFD). The colonic epithelial cells were isolated and gene expression profiles were analyzed by GeneChip.
2014-08-11 | GSE41104 | GEO
Project description:In a study using syngeneic BALB/c mice, the impact of a high-fat diet (HFD) on triple-negative breast cancer (TNBC) progression was investigated using 4T1 cells. Mice were fed either a low-fat diet (LFD) or HFD for six weeks before receiving orthotopic injections of 4T1 cells. Post-tumor formation, mice were randomized into three groups: LFD, HFD, and HFD with EC359 treatment. Results indicated that HFD significantly enhanced tumor growth, while EC359 treatment notably reduced HFD-induced TNBC progression. To explore underlying mechanisms, global RNA sequencing was performed on tumor tissues, revealing that HFD altered the expression of 578 genes compared to LFD, with 325 genes differentially expressed between the HFD and HFD + EC359 groups. Gene set enrichment analysis showed that HFD-related genes were linked to cytokine signaling, inflammation, stem cell pathways, TGFβ, metastasis, and epithelial–mesenchymal transition, all of which were downregulated with EC359 treatment.
2024-11-14 | GSE280092 | GEO
Project description:To investigate the effect of diet and Yap KD on liver matastasis, we injected MC38 cells in LFD-fed or HFD-fed mice, and MC38 with shCon or shRNA for Yap (shYap1) in HFD-fed mice We then performed gene expression profiling analysis using data obtained from RNA-seq of these 4 different conditions
2023-05-11 | GSE227913 | GEO
Project description:To investigate the transcriptional profiles of adipocytes and stromal vascular cells from mouse visceral adipose tissue(vWAT) in lean (Low fat diet, LFD fed), obese (high fat diet, HFD fed) and formerly obese (diet switch (SW) from 9 weeks HFD, to 3 weeks LFD) to induce weight loss.
2022-08-04 | GSE210014 | GEO
Project description:To investigate the effect of diet and Yap KD on liver matastasis, we injected MC38 cells in LFD-fed or HFD-fed mice, and MC38 with shCon or shRNA for Yap (shYap1) in HFD-fed mice We then performed gene expression profiling analysis in various cell types using data obtained from single cell RNA-seq of these 4 different conditions
2023-05-11 | GSE227914 | GEO
Project description:Chronic exposure to inorganic arsenic (iAs) or a high-fat diet (HFD) can produce liver injury. However, the interactive molecular biological effects and mechanism of iAs and HFD are as of yet unclear. We used microarrays to detail the interactive effects of arsenic and a high-fat diet on hepatic gene expression. The C57BL/6 Mice fed low-fat diet (LFD) or HFD were exposed to 3 mg/L iAs or deionized water for 10 weeks. Then, hepatic RNA were extraction and hybridization on Affymetrix microarrays. Differentially expressed genes in LFD+As, HFD, and HFD+As groups compared to LFD group were identified, and interactive molecular biological effects and mechanism of iAs and HFD were discussed.
2013-11-30 | E-GEOD-52702 | biostudies-arrayexpress
Project description:Gene expression for genes differentially expressed between early vs. late tumor onset and high fat diet (HFD) vs. low fat diet (LFD) in P53 -/- mice. 4 HFD early tumor onset, 7 HFD late tumor onset, 4 HFD to LFD switch with early tumor onset, 6 HFD to LFD switch with late tumor onset, 4 LFD early tumor onset, 7 LFD late tumor onset, 5 LFD to HFD switch with early tumor onset, 4 LFD to HFD switch with late tumor onset
2015-10-24 | E-GEOD-74294 | biostudies-arrayexpress
Project description:Gene expression of colonic epithelial cells in starved and re-fed mice
| PRJNA173779 | ENA
Project description:The composition of the diet affects many processes in the body, including body weight and endocrine system. We have previously shown that dietary fat also affects the immune system. Mice fed high fat diet rich in polyunsaturated fatty acids survive S. aureus infection to a much greater extent than mice fed high fat diet rich in saturated fatty acids. Here we present data regarding the dietary effects on protein expression in spleen from mice fed three different diets, I) low fat/chow diet (LFD, n=4), II) high fat diet rich in saturated fatty acids (HFD-S, n=4) and III) high fat diet rich in polyunsaturated fatty acids (HFD-P, n=4). We performed mass spectrophotometry based quantitative proteomics analysis of isolated spleen by implementing the isobaric tags for relative and absolute quantification (iTRAQ) approach. Mass spectrometry data were analysed using Proteome Discoverer 2.4 software using the search engine mascot against Mus musculus in SwissProt. 924 proteins are identified in all sets (n=4) for different dietary effects taken for statistical analysis using Qlucore Omics Explorer software. Only 20 proteins were found to be differentially expressed with a cut-off value of false discovery rate < 0.1 (q-value) when comparing HFD-S and HFD-P but no differentially expressed proteins were found when LFD was compared with HFD-P or HFD-S. We identified a subset of proteins that showed an inverse expression pattern between two high fat diets. These differentially expressed proteins were further classified by gene ontology for their role in biological processes and molecular functions.
2020-08-06 | PXD020365 | Pride