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Drosophila melanogaster

ABSTRACT: Genome-wide binding of Yki and GAF in embryos and wing imaginal discs [RNA-Seq]

PROVIDER: PRJNA184675 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR639486.fastq.gz	Fastqsanger.gz
	SRR639487.fastq.gz	Fastqsanger.gz
	SRR639488.fastq.gz	Fastqsanger.gz
	SRR639489.fastq.gz	Fastqsanger.gz

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Project description:Genome-wide binding of Yki and GAF in embryos and wing imaginal discs [ChIP-Seq]

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Project description:Promoter proximal pausing (PPP) of RNA Polymerase II has emerged as a crucial rate-limiting-step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT) and the Negative Elongation Factor (NELF) which are highly conserved from Drosophila to humans. Here we show that RNAi-mediated depletion of bin3 or Hexim of the 7SK snRNP complex or depletion of individual components of the NELF complex enhance Yki-driven growth leading to neoplastic transformation of Drosophila wing imaginal discs. We also show that increased CDK9 expression cooperates with Yki, in driving neoplastic growth. Interestingly, over-expression of CDK9 on its own or in the background of depletion of one of the components of 7SK snRNP or the NELF complex necessarily and specifically needed Yki over-expression to cause tumorous growth. Genome-wide gene expression analyses suggested that deregulation of protein homeostasis is associated with tumorous growth of wing imaginal discs. As both Fat/Hippo/Yki pathway and PPP are highly conserved, our observations may provide insights into mechanisms of oncogenic function of YAP, the orthologue of Yki in human.

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