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Babesia bovis T2Bo

ABSTRACT: A tick-transmitted parasite of cattle

PROVIDER: PRJNA18731 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	AAXT01.dat.gz	Other
	AAXT01.fasta.gz	Fasta.gz
	AAXT01.master.dat	Other
	AAXT01.dat.gz	Other

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Project description:Babesia parasites transition between a mammalian host, where they cause babesiosis, and the tick vector that transmits them. This transition provides an environmental signal resulting in altered gene expression allowing the completion of the parasite’s life cycle. A comparison of the different life stages that occur within mammalian and tick hosts can provide insight into the adaptation of Babesia to these different environments. In this study, we used RNA-Seq to compare gene expression between Babesia bovis blood stages and tick derived kinetes.

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Comparison of high throughput RNA sequences between Babesia bigemina and Babesia bovis revealed consistent differential gene expression that is required for Babesia life cycle in the vertebrate and invertebrate hosts.

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Project description:This project aimed to discover the protein-based biomarkers for tick resistance in cattle using cattle serum samples. The cattle were phenotyped into two groups, tick-resistant and susceptible after an artificial tick challenge. Mean tick scores were used to categorise cattle. The SWATH analysis was sued to measure the relative abundance of proteins in skin samples of the two groups at different time points.

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Biomarker discovery for ectoparasite host resistance in cattle

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