Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Escherichia coli O127:H6 str. E2348/69 substr. UMD753

ABSTRACT: Escherichia coli O127:H6 str. E2348/69 substr. UMD753 Genome sequencing and assembly

PROVIDER: PRJNA204937 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ASZS01.dat.gz	Other
	ASZS01.fasta.gz	Fasta.gz
	ASZS01.master.dat	Other
	ASZS01.dat.gz	Other

Items per page:

1 - 4 of 4

Similar Datasets

Escherichia coli O127:H6 str. E2348/69 substr. CVDNalr

Project description:Escherichia coli O127:H6 str. E2348/69 substr. CVDNalr Genome sequencing and assembly

| PRJNA204931 | ENA

Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69.

Project description:Enteropathogenic Escherichia coli (EPEC) was the first pathovar of E. coli to be implicated in human disease; however, no EPEC strain has been fully sequenced until now. Strain E2348/69 (serotype O127:H6 belonging to E. coli phylogroup B2) has been used worldwide as a prototype strain to study EPEC biology, genetics, and virulence. Studies of E2348/69 led to the discovery of the locus of enterocyte effacement-encoded type III secretion system (T3SS) and its cognate effectors, which play a vital role in attaching and effacing lesion formation on gut epithelial cells. In this study, we determined the complete genomic sequence of E2348/69 and performed genomic comparisons with other important E. coli strains. We identified 424 E2348/69-specific genes, most of which are carried on mobile genetic elements, and a number of genetic traits specifically conserved in phylogroup B2 strains irrespective of their pathotypes, including the absence of the ETT2-related T3SS, which is present in E. coli strains belonging to all other phylogroups. The genome analysis revealed the entire gene repertoire related to E2348/69 virulence. Interestingly, E2348/69 contains only 21 intact T3SS effector genes, all of which are carried on prophages and integrative elements, compared to over 50 effector genes in enterohemorrhagic E. coli O157. As E2348/69 is the most-studied pathogenic E. coli strain, this study provides a genomic context for the vast amount of existing experimental data. The unexpected simplicity of the E2348/69 T3SS provides the first opportunity to fully dissect the entire virulence strategy of attaching and effacing pathogens in the genomic context.

| S-EPMC2612414 | biostudies-literature

EPEC-E2348/69-V2

Project description:EPEC E2348/69 variety 2. Wild-type strain.

| PRJEB18716 | ENA

Escherichia coli O127:H6 str. E2348/69

Project description:Enteropathogenic strain

| PRJEA32571 | ENA

Escherichia coli O127:H6 str. E2348/69

Project description:Identification of transcriptional pathways associated with enviromental modification

| PRJNA237642 | ENA

Escherichia coli O127:H6 str. E2348/69

Project description:Comparative genomics provides insight into the diversity of the attaching and effacing Escherichia coli (AEEC) virulence plasmids

| PRJNA285331 | ENA

Massilia sp. H6 strain:H6

Project description:Massilia sp. H6 strain:H6 Genome sequencing

| PRJNA865807 | ENA

RIL-seq of EPEC E2348/69 hfq-flag, in virulence activating and non-activating conditions.

Project description:RIL-seq of EPEC E2348/69 hfq-flag, in virulence activating and non-activating conditions.

| PRJEB36843 | ENA

Microbacterium sp. H6 strain:H6

Project description:Microbacterium sp. H6 strain:H6 Genome sequencing and assembly

| PRJNA479897 | ENA

Campylobacter coli H6 strain:H6

Project description:Campylobacter coli H6 genome sequencing