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Homo sapiens

ABSTRACT: Genomewide analysis of the human p53 transcriptional network unveils a lncRNA tumor suppressor signature (ChIP-seq)

PROVIDER: PRJNA252830 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1409974.fastq.gz	Fastqsanger.gz
	SRR1409975.fastq.gz	Fastqsanger.gz

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Project description:Genomewide analysis of the human p53 transcriptional network unveils a lncRNA tumor suppressor signature

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Project description:p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it partly shifts p53’s conformation and transcriptional output towards a state resembling cancer-associated p53 mutants, and endow p53 with the ability to promote cell migration. Notably, LATS1 and LATS2 are frequently downregulated in breast cancer; we propose that such downregulation might benefit cancer by converting p53 from a tumor suppressor into a tumor facilitator.

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