Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA252831 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Genomewide analysis of the human p53 transcriptional network unveils a lncRNA tumor suppressor signature (ChIP-seq)
| PRJNA252830 | ENA
Project description:Genomewide analysis of the human p53 transcriptional network unveils a lncRNA tumor suppressor signature (RNA-seq)
| PRJNA252833 | ENA
Project description:Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and lncRNAs in nasopharyngeal carcinoma (NPC) remain unclear. The aim of this study was to investigate the regulatory roles of the TP53 gene in regulating lncRNA and mRNA expression profiles in NPC cell line HNE2. p53 induced gene expression in human nasopharyngeal carcinoma cell line HNE2 was measured at 0, 12, 24 and 48 hours after transfected by pCMV-p53 plasmid.
2015-05-14 | E-GEOD-60379 | biostudies-arrayexpress
Project description:Maternally Expressed Gene 3 (MEG3) encodes a lncRNA which is suggested to function as a tumor suppressor. MEG3 functions as a tumor suppressor in hepatoma cells, whose action is mediated by interaction with p53 protein to activate p53-mediated transcriptional activity and influence the expression of partial p53 target genes. Total RNA was isolated from hepatoma cells (HepG2 and SK-Hep-1) transfected with either control or MEG3 overexpression/knockdown constructs for global expression analysis.
2015-06-17 | E-GEOD-69916 | biostudies-arrayexpress
Project description:Maternally Expressed Gene 3 (MEG3) encodes a lncRNA which is suggested to function as a tumor suppressor. MEG3 functions as a tumor suppressor in hepatoma cells, whose action is mediated by interaction with p53 protein to activate p53-mediated transcriptional activity and influence the expression of partial p53 target genes.
2015-06-17 | GSE69916 | GEO
Project description:p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it partly shifts p53’s conformation and transcriptional output towards a state resembling cancer-associated p53 mutants, and endow p53 with the ability to promote cell migration. Notably, LATS1 and LATS2 are frequently downregulated in breast cancer; we propose that such downregulation might benefit cancer by converting p53 from a tumor suppressor into a tumor facilitator.
2018-10-25 | PXD003120 | Pride
Project description:Residual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
2018-06-04 | E-MTAB-6774 | ExpressionAtlas
Project description:Here we identify PURB, a dual DNA/RNA-binding protein, as a key mediator for LncRNAs to interact with p53. PURB is overexpressed in human cancers and loss of PURB expression in human cancer cells induces tumor growth suppression by activating p53. Interestingly, PURB knockdown activates only a subset of p53 target genes without affecting p53 protein levels and PURB is specifically recruited by p53 to the target genes in a promoter-specific manner. Moreover, a unique cis-regulatory element is identified at the target promoters recognized by PURB; loss of this element does not affect p53-mediated transactivation but abrogates the ability of p53 to recruit PURB to the promoters for repression. Notably, the ability of PURB in transcriptional repression requires its sequence-specific binding with HOTAIR, one of LncRNAs tightly associated with PURB. HOTAIR interacts directly with SUV39H1 and, bridging by the PURB/HOTAIR complex, p53 is able to recruit SUV39H1 histone methyltransferase to the target promoters for transcriptional repression. These data establish a new mode of LncRNA-mediated regulation of p53 transcription in a sequence-specific manner and also reveal, a previously unanticipated mechanism for promoter-specific regulation through a unique cis-regulatory element recognized by the LncRNA-protein complex.
2025-04-24 | PXD042681 | Pride
Project description:A microRNA component of the p53 tumor suppressor network
| PRJNA100005 | ENA