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Caenorhabditis elegans

ABSTRACT: Whole genome microRNA expression profiling of long-lived daf-2(e1370) mutant in C. elegans at young adult stage

PROVIDER: PRJNA260270 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1565822.fastq.gz	Fastqsanger.gz
	SRR1568274.fastq.gz	Fastqsanger.gz

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Whole genome microRNA expression profiling of long-lived daf-2(e1370) mutant in C. elegans at young adult stage

Project description:In order to get an insight into the complex interplay of miRNAs in insulin signaling, we profiled the small RNA polulation of daf-2(e1370) worms at young adult stage by Next Generation sequencing. We performed Next Generation sequencing to compare miRNA profiles of wild-type and long-lived daf-2(e1370) mutant at young adult stage

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Project description:Synchronized C. elegans cultures of three geontypes -- wildype N2, daf-2(e1370) and sma-6(wk7) -- were prepared using standard techniques (http://cmgm.stanford.edu/~kimlab/index_methods.html). Live young adult worms were split between NG plates pre-seeded with the non-pathogenic E. coli strain OP50 or the Pseudomonas aeruginosa clinical isolate PA14 and incubated at 25C for 4 or 24 hours before harvesting. This experiment was repeated at least three times on independent occasions. cDNA probes were prepared from experimental samples and from reference mRNA extracted from mixed stage wild type worms grown at 25C, and were labeled with Cy3 or Cy5, as indicated. A reference experiement design type is where all samples are compared to a common reference. Elapsed Time: Time Infection: Exposure to the non-pathogenic E. coli strain OP50 or to the pathogenic Pseudomonas aeruginosa strain PA14 Strain Name: C. elegans wildtype strain N2 or the immune pathway mutants daf-2(e1370) or sma-6(wk7) Keywords: reference_design Computed

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