Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transfer RNAs mediate rapid adaptation of Escherichia coli under oxidative stress

ABSTRACT: Transfer RNAs mediate rapid adaptation of Escherichia coli under oxidative stress

OTHER RELATED OMICS DATASETS IN: GSE62995

PROVIDER: PRJNA266390 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1640552.fastq.gz	Fastqsanger.gz
	SRR1640553.fastq.gz	Fastqsanger.gz
	SRR1640554.fastq.gz	Fastqsanger.gz
	SRR1640555.fastq.gz	Fastqsanger.gz
	SRR1640556.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Transfer RNAs mediate rapid adaptation of Escherichia coli under oxidative stress

Project description:We performed tRNAome sequencing to assess the tRNA changes of E.coli under oxidative stress. We found that the global translation inhibition is caused by global down-regulation of almost all tRNA species under oxidative stress. The translation elongation speed is resumed after the cells are fully adapted to the oxidative environment.

2015-05-28 | GSE62995 | GEO

Transfer RNAs Mediate the Rapid Adaptation of Escherichia coli to Oxidative Stress.

Project description:Translational systems can respond promptly to sudden environmental changes to provide rapid adaptations to environmental stress. Unlike the well-studied translational responses to oxidative stress in eukaryotic systems, little is known regarding how prokaryotes respond rapidly to oxidative stress in terms of translation. In this study, we measured protein synthesis from the entire Escherichia coli proteome and found that protein synthesis was severely slowed down under oxidative stress. With unchanged translation initiation, this slowdown was caused by decreased translation elongation speed. We further confirmed by tRNA sequencing and qRT-PCR that this deceleration was caused by a global, enzymatic downregulation of almost all tRNA species shortly after exposure to oxidative agents. Elevation in tRNA levels accelerated translation and protected E. coli against oxidative stress caused by hydrogen peroxide and the antibiotic ciprofloxacin. Our results showed that the global regulation of tRNAs mediates the rapid adjustment of the E. coli translation system for prompt adaptation to oxidative stress.

| S-EPMC4474833 | biostudies-literature

Bacterial rapid adaptation to alkaline environments

Project description:Bacterial rapid adaptation to alkaline environments

| PRJNA1125898 | ENA

Adaptation of pathogenic Leptospira to oxidative stress

Project description:Adaptation of pathogenic Leptospira to oxidative stress

| PRJNA588039 | ENA

Bacterial rapid adaptation to alkaline environments

Project description:To investigate the rapid adaptation mechanism of Bacillus thuringiensis in an alkaline environment, we have employed whole genome microarray expression profiling as a discovery platform to identify the difference of gene expression between normal condition and alkaline condition.

2024-06-24 | GSE270261 | GEO

FIBR - genomics of rapid adaptation

Project description:FIBR - study to investigate rapid genomic adaptation in experimental populations of guppies (Poecilia reticulata)

| PRJEB42705 | ENA

Genomics of rapid adaptation to antibiotics

Project description:Genomics of rapid adaptation to antibiotics: Convergent evolution and scalable sequence amplification.

| PRJEB4687 | ENA

Plant 22-nt siRNAs mediate translational repression and stress adaptation

Project description:Plant 22-nt siRNAs mediate translational repression and stress adaptation

| PRJNA560787 | ENA

Plant 22-nt siRNAs mediate translational repression and stress adaptation

Project description:Plant 22-nt siRNAs mediate translational repression and stress adaptation