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LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

ABSTRACT: LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

PROVIDER: PRJNA326395 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7084440_1.fastq.gz	Fastqsanger.gz
	SRR7084440_2.fastq.gz	Fastqsanger.gz
	SRR7084441_1.fastq.gz	Fastqsanger.gz
	SRR7084441_2.fastq.gz	Fastqsanger.gz
	SRR7084442_1.fastq.gz	Fastqsanger.gz

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LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [nude mice]

Project description:We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 Nu/Nu mice Tumor-bearing bone marrows of three Sca1-TOMATO-Lmo2 Nu/Nu mice compared with bone marrow cells from four Control Nude mice and with thymus leukemic cells from ten Sca1-TOMATO-Lmo2 mice. GSM2209767 - GSM2209776 are re-analyses of GSE83570 (GSM2209749 - GSM220975 and GSM2209757 - GSM2209759).

2016-06-22 | E-GEOD-83571 | biostudies-arrayexpress

LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [preleukemic and leukemic cells]

Project description:We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 mice and in preleukemic cells from Sca1-TOMATO-Lmo2 mice. Tumor-bearing thymus of eleven Sca1-TOMATO-Lmo2 mice compared with thymus cells from 4 WT mice, with TOMATO-positive thymus preleukemic T cells from 5 Sca1-TOMATO-Lmo2 mice and with TOMATO-negative thymus preleukemic T cells from 5 Sca1-TOMATO-Lmo2 mice GSM2209749 - GSM220975 and GSM2209757 - GSM2209759 were re-analyzed by GSE83571 (GSM2209767 - GSM2209776).

2016-06-22 | E-GEOD-83570 | biostudies-arrayexpress

LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [nude mice]

Project description:We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 Nu/Nu mice

2016-06-22 | GSE83571 | GEO

LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [preleukemic and leukemic cells]

Project description:We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 mice and in preleukemic cells from Sca1-TOMATO-Lmo2 mice.

2016-06-22 | GSE83570 | GEO

LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-06-22 | E-GEOD-83572 | biostudies-arrayexpress

LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-06-22 | GSE83572 | GEO

The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

Project description:Relapse in T-cell acute lymphoblastic leukemia (T-ALL) may signify the persistence of leukemia-initiating cells (L-ICs). Ectopic TAL1/LMO expression defines the largest subset of T-ALL, but its role in leukemic transformation and its impact on relapse-driving L-ICs remain poorly understood. In TAL1/LMO mouse models, double negative-3 (DN3; CD4−CD8−CD25+CD44−) thymic progenitors harbored L-ICs. However, only a subset of DN3 leukemic cells exhibited L-IC activity, and studies linking L-ICs and chemotolerance are needed. To investigate L-IC heterogeneity, we used mouse models and applied single-cell RNA-sequencing and nucleosome labeling techniques in vivo. We identified a DN3 subpopulation with a cell cycle–restricted profile and heightened TAL1/LMO2 activity, that expressed genes associated with stemness and quiescence. This dormant DN3 subset progressively expanded throughout leukemogenesis, displaying intrinsic chemotolerance and enrichment in genes linked to minimal residual disease. Examination of TAL/LMO patient samples revealed a similar pattern in CD7+CD1a− thymic progenitors, previously recognized for their L-IC activity, demonstrating cell cycle restriction and chemotolerance. Our findings substantiate the emergence of dormant, chemotolerant L-ICs during leukemogenesis, and demonstrate that Tal1 and Lmo2 cooperate to promote DN3 quiescence during the transformation process. This study provides a deeper understanding of TAL1/LMO-induced T-ALL and its clinical implications in therapy failure.

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The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

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The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

Project description:The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

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The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

Project description:The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance

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