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LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Isidro SÃ¡nchez GarcÃa

PROVIDER: E-GEOD-83572 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [nude mice]

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2016-06-22 | E-GEOD-83571 | biostudies-arrayexpress

LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [preleukemic and leukemic cells]

Project description:We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 mice and in preleukemic cells from Sca1-TOMATO-Lmo2 mice. Tumor-bearing thymus of eleven Sca1-TOMATO-Lmo2 mice compared with thymus cells from 4 WT mice, with TOMATO-positive thymus preleukemic T cells from 5 Sca1-TOMATO-Lmo2 mice and with TOMATO-negative thymus preleukemic T cells from 5 Sca1-TOMATO-Lmo2 mice GSM2209749 - GSM220975 and GSM2209757 - GSM2209759 were re-analyzed by GSE83571 (GSM2209767 - GSM2209776).

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LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-06-22 | GSE83572 | GEO

LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [nude mice]

Project description:We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 Nu/Nu mice

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LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [preleukemic and leukemic cells]

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LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

Project description:LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche

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Niche-less maintenance of HSCs by 2i.

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