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Mus musculus

ABSTRACT: RNAseq changes in fibroblasts after treatment with selected protein(s) or E16.5 skin extract

PROVIDER: PRJNA337890 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4004735_1.fastq.gz	Fastqsanger.gz
	SRR4004735_2.fastq.gz	Fastqsanger.gz
	SRR4010250_1.fastq.gz	Fastqsanger.gz
	SRR4010250_2.fastq.gz	Fastqsanger.gz
	SRR4010251_1.fastq.gz	Fastqsanger.gz

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RNAseq changes in fibroblasts after treatment with selected protein(s) or E16.5 skin extract

Project description:Purpose: To identify the cellular processes upregulated in fibroblasts after treatment with selected protein(s) or E16.5 skin extract Methods: To explore the mechanism of extract-induced HF neogenesis, adult dermal fibroblasts were cultured in the presence of E16.5 extract or selected protein(s) for 3 days before being tested. Results: we determined how the exposure of adult fibroblasts to E16.5 extract, the selected protein mix or each of the selected proteins and compared the resultant transcriptomes with those of adult DP and embryonic dermal fibroblasts. Conclusions: Gene expression of adult fibroblasts exposed to E16.5 extract and selected proteins mix, the key DP signature genes became upregulated.

2016-08-10 | GSE85303 | GEO

RNAseq changes in fibroblasts after treatment with selected protein(s) or E16.5 skin extract

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Project description:RNAseq changes in human fibroblasts after treatment with E16.5 skin extract

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RNAseq changes in human fibroblasts after treatment with E16.5 skin extract

Project description:To identify the cellular processes upregulated in fibroblasts after treatment with E16.5 skin extract

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Project description:RNAseq changes in mouse skin after treatment with external light

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RNAseq of quiescent (Q) and stress induced premature senescent (SIPS) fibroblasts treated with plant extract (1201) from Solidago vigaurea subspecies alpestris

Project description:Quiescent (Q) and stress induced premature senescent (SIPS) fibroblasts were treated for the duration of 4 days with growth medium supplemented with a plant extract (1201) from Solidago vigaurea subspecies alpestris. Rna was isolated with Trizol and sent to GATC for next generation sequencing with Ilumina technology. The plant extract proofed to block the negative effects of senescence in human skin fibroblasts in various experiments by delaying the acquisition of a senescent phenotype/favouring a papillary-like phenotype and attenuating the senescence associated secretory phenotype. The RNAseq was performed to understand the underlying molecular mechanism of the observed effects. SIPS was induced by chronic oxidative stress treatment (9 days with 1 h 100 µM H2O2 per day).

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Serpinb3a contributes to early skin inflammation following allergen exposure

Project description:Serpinb3a knockout mice show attenuated Transepidermal Water Loss (TEWL) and S100A8 expression (an early inflammatory marker) following treatment with Aspergillus fumigatus extract. The aim of the RNAseq experiments was to provided mechanistic insight for the role of Serpinb3a by identifying early differences in gene expression following allergen exposure. Wild type Balb/c and Serpinb3a null mouse backs were shaved and 24 hours later a patch containing 200ug of Aspergillus fumigatus extract was applied to the skin. After 3 days the patch was removed and the skin was harvested after an additional 24 hours.

2014-10-01 | E-GEOD-54640 | biostudies-arrayexpress

Identification of early and late responder genes during cell reprogramming of mouse fibroblasts into induced pluripotent stem cells

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Project description:A subset of human skin fibroblasts are phagocytic. To investigate the gene expression changes between phagocytosing and non-phagocytosing fibroblasts, fibroblasts were incubated with apoptotic human dermal microvascular endothelial cells expressing green fluorescent protein or no treatment. Treated fibroblasts were then collected after 8 hours and sorted by FACS to identify phagocytic and non-phagocytic fibroblasts. We then performed gene expression profiling analysis using data obtained from RNA-seq of these three groups of cells.

2023-06-01 | GSE224202 | GEO

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