Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Transcriptome analysis of Bcl11b mutant CD4+CD8+ thymocytes

PROVIDER: PRJNA354517 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5043810.fastq.gz	Fastqsanger.gz
	SRR5043811.fastq.gz	Fastqsanger.gz
	SRR5043812.fastq.gz	Fastqsanger.gz
	SRR5043813.fastq.gz	Fastqsanger.gz
	SRR5043814.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Mus musculus

Project description:Gene expression analysis of CD4+ CD8+ thymocytes [Affymetrix]

| PRJNA243031 | ENA

Mus musculus

Project description:Gene expression analysis of Ets1-/- CD4+ CD8+ thymocytes

| PRJNA298222 | ENA

Identification of genomic associations of transcription factors BCL11B, Ikaros, and Mi2beta in primary mouse thymocytes

Project description:BCL11B and Ikaros, transcription factors essential to normal development and maturation of T cells are associated with the Mi2-beta NuRD complex in CD4+ CD8+ double-positive thymocytes.

2021-12-31 | GSE59826 | GEO

The interactomes of RUNX1 and RUNX3 from Mus musculus T cells

Project description:Cellular binary fate decisions require the progeny to silence genes associated with the alternative fate. The major subsets of alpha:beta T cells have been extensively studied as a model system for fate decisions. While the transcription factor RUNX3 is required for the initiation of Cd4 silencing in CD8 T cell progenitors, it is not required to maintain the silencing of Cd4 and other helper T lineage genes. The other runt domain containing protein, RUNX1, silences Cd4 in an earlier T cell progenitor, but this silencing is reversed whereas the gene silencing after RUNX3 expression is not reverse. Therefore, we hypothesized that RUNX3 and not RUNX1 recruits other factors that maintains the silencing of helper T lineage genes in CD8 T cells. To this end, we performed a proteomics screen of RUNX1 and RUNX3 to determine candidate silencing factors.

2019-11-12 | PXD007511 | Pride

Mus musculus

Project description:Mapping of H2A.Z nucleosomes in CD4/CD8 DP thymocytes

| PRJNA345022 | ENA

Mus musculus

Project description:SOX13 regulated genes in CD4+CD8+ double positive thymocytes

| PRJNA100519 | ENA

Bcl11b hypomorphic mutant thymocytes

Project description:Bcl11b hypomorphic mutant thymocytes

| PRJNA356604 | ENA

Gene expression profiling of thymocytes from conditional knock-out mice (FoxN1-Cre mediated KO of Gpr177)

Project description:Comparative gene expression profiling of thymocytes at the DP, CD4 SP and CD8 SP stage derived from FoxN1-Gpr177 mice (FoxN1-Cre mediated deletion of (Exon3 of) Gpr177/Wtls) or C57Bl/6N mice as comparison. Objective was to test the influence of TEC-secreted Wnt ligands on the transcriptome of thymocytes at the respective developmental stages. Total RNA extracted from FACS-sorted primary mouse thymocytes. CD4/8 double positive (DP) thymocytes, CD4 single positive (CD4 SP) thymocytes and CD8 single positive (CD8 SP) thymocytes were FACS-sorted from conditional knock-out mice (FoxN1-Gpr177) and C57Bl/6N mice as comparison.

2015-11-01 | E-GEOD-69766 | biostudies-arrayexpress

Impact of Tcf1 and Lef1 deficiency on mature CD8 thymocytes

Project description:Comparison of transcriptome between control and Tcf1/Lef1-deficient mature CD8 thymocytes Control mice or those are deficient for Tcf1 and Lef1 transcription factors (deleted by CD4-Cre) were used to isolate thymocytes. The thymocytes were surface-stained to identify TCRbeta high, CD69â, CD24â CD8+ subsets. These cells were sorted for RNAseq analysis.

2016-02-12 | E-GEOD-73238 | biostudies-arrayexpress

Mus musculus

Project description:Chromatin structures in pre-selection DP thymocytes of WT and Bcl11b hypomorphic mutant

| PRJNA356605 | ENA