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Staphylococcus saprophyticus

ABSTRACT: Commensal Staphylococcal species that can cause acute urinary tract infections

PROVIDER: PRJNA35739 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR10140032_subreads.fastq.gz	Fastqsanger.gz
	SRR10140033_subreads.fastq.gz	Fastqsanger.gz
	SRR10140034_subreads.fastq.gz	Fastqsanger.gz
	SRR10140035_subreads.fastq.gz	Fastqsanger.gz

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Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292

Project description:Commensal Staphylococcal species that can cause acute urinary tract infections

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Expression data from human neutrophils exposed to uropathogenic and commensal Esherichia coli.

Project description:The establishment of bacterial infections at epithelial surfaces is determined by the balance of virulence attributes of the pathogen with the activity of innate host defenses. Polymorphonuclear leukocytes (PMN) are key responders in many bacterial infections, but the mechanisms by which pathogens subvert these early responses to establish infection are largely undefined. Here, we model these early interactions between human PMN and the primary cause of urinary tract infections, namely uropathogenic Escherichia coli (UPEC). Our objective was to define virulence phenotypes of uropathogens (as compared with laboratory and commensal E. coli strains) that permit evasion of PMN activity. We found that UPEC strains resist phagocytic killing and dampen the production of antimicrobial reactive oxygen species by PMNs. Analysis of the global transcriptional responses of PMN to E. coli strains revealed that UPEC exposure downregulates the expression of PMN genes involved in proinflammatory signaling and PMN chemotaxis, adhesion, and migration. Consistent with these data, UPEC attenuated transepithelial neutrophil recruitment in an in vitro model of acute infection. We propose that these UPEC strategies are important in the establishment of epithelial infection, and that the findings are germane to a range of bacterial infections at epithelial surfaces. We used microarrays to detail the global program of gene expression in human neutrophils in response to a uropathogenic bacteria compared to a closely related non-pathogenic strain relative to control samples with no bacteria. Our goal was to elucidate a pathogen-specific response. We chose an early time point of 60 minutes to evaluate the accute response to infection. Human neutrophils were exposed to pathogenic or commensal Escherichia coli for RNA extraction and hybridization on Affymetrix microarrays

2010-03-07 | E-GEOD-18810 | biostudies-arrayexpress

Transcriptional responses of uropathogenic E. coli to stresses caused by sodium chloride or urea.

2012-04-05 | GSE28399 | GEO

Transcriptional responses of uropathogenic E. coli to stresses caused by sodium chloride or urea.

Project description:E. coli which cause urinary tract infections must respond to high osmolarity in the urinary tract as well as the presence of urea. We used microarrays to measure the differntial gene expression of uropathogenic strain CFT073 in conditions of high osmolarity of urea v. minimal media RNA was extracted from CFT073 in each growth condition and hybridized to an Affymetrix microarray. The differentially expressed genes were analyzed by expression pattern and function.

2012-04-04 | E-GEOD-28399 | biostudies-arrayexpress

Using a Zebrafish Model to Identify Cellular Responses to Uropathogenic E. coli Bacteremia

Project description:Urinary tract infections (UTIs) are the second most common infections encountered in the pediatric population, second only to respiratory tract infections. UTIs are also a major cause of morbidity and mortality. UTIs can often ascend causing infection in the upper urinary tract or even progress to bacteremia or urosepsis. Urosepsis accounts for 10-30% of septic shock cases and Uropathogenic E.coli (UPEC) is responsible for almost 75% of cases. Therefore, increased understanding of the effects of urosepsis at the cellular and organ specific level will provide the foundation for improvements in clinical care.

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THE EXOPROTEOME PROFILES OF THREE STAPHYLOCOCCUS SAPROPHYTICUS STRAINS REVEAL DIVERSITY IN PROTEIN SECRETION CONTENT

Project description:Staphylococcus saprophyticus is a gram-positive microorganism responsible for urinary tract infections (UTIs). Although some virulence factors have been characterized, such as urease, autolysins, adhesins, hemagglutinins and cell wall proteins, large-scale proteomic studies have not been performed within this species. In our research, we performed the characterization of the exoproteome from three clinical S. saprophyticus strains (ATCC 15305-capsular strain, 7108 non-capsular strain and 9325, a strain containing a thick capsule) which were cultured until the stationary phase of bacterial growth by using mass spectrometry approach. In these strains we observed a core of 72 secreted proteins. In addition, we identified proteins that were not secreted by all the strains. It was possible to detect diversity in the protein profiles of the exoproteomes, and consequently proteins that were differentially expressed were identified. Interestingly, strain 7108 presented no secretion of three antigenic proteins, including the classical SsaA antigen. In addition, the level of antigenic proteins secreted by strain 9325 was higher than in ATCC 15305. This result was confirmed by Western blot analysis using anti-SsaA polyclonal antibodies, and no production or secretion of SsaA was detected in strain 7108. Moreover, when compared with the other strains that were analyzed, it was possible to detect higher levels of proteases secreted by strain 7108. The results reveal diversity in protein secretion among strains. This research is an important first step towards understanding the variability in S. saprophyticus and could be significant in explaining differences in virulence.

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Corynebacterium urealyticum DSM 7109

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Project description:We profiled both fractions of the urinary proteome for 33 human subjects with varied pathologies such as urinary tract infection (UTI), urogenital injury and commensal bacteria colonization. Using a LC-MS/MS based metaproteomic approach, we identified 5,327 non-redundant human proteins, 2,638 and 4,379 of which were associated with soluble urine (SU) and urinary pellet (UP) fractions, respectively, and approximately 1,206 non-redundant protein orthology groups derived from pathogens and commensal organisms of the urogenital tract

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