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Homo sapiens

ABSTRACT: Transcriptome comparison of balding and non-balding dermal papilla aggregates from NHEK co-culturing

PROVIDER: PRJNA362329 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5184340_1.fastq.gz	Fastqsanger.gz
	SRR5184340_2.fastq.gz	Fastqsanger.gz
	SRR5184331_1.fastq.gz	Fastqsanger.gz
	SRR5184331_2.fastq.gz	Fastqsanger.gz
	SRR5184341_1.fastq.gz	Fastqsanger.gz

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Transcriptome comparison of balding and non-balding dermal papilla aggregates from NHEK co-culturing

Project description:Androgenetic alopecia (AGA, male patterned baldness) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. The keratinocytes-surrounded spheroid dermal papilla (DP) at the base of the hair follicle is essential in hair morphogenesis and cycling. With the aim of elucidating genes involved in AGA pathogenesis, we co-cultured immortalised balding and non-balding human DP cells (DPC) derived from male AGA patients with epidermal keratinocyte (NHEK) using multi-interfacial polyelectrolyte complexation (MIPC) technique, and compared gene expression using RNA-seq between isolated balding and non-balding DP aggregates.

2021-06-23 | GSE93766 | GEO

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Project description:Dermal papilla signature gene expression in immortalized human dermal papilla cells from balding and non-balding scalp

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Dermal papilla signature gene expression in immortalized human dermal papilla cells from balding and non-balding scalp

Project description:Transcriptome analysis of DP signature gene expression in hTERT-immortalized balding (BAB) and non-balding (BAN) dermal papilla cells derived from frontal and occipital scalp of male patients with androgenetic alopecia Hamilton grade IV.

2016-04-20 | GSE66663 | GEO

RNA-seq of 3D-culture balding and non-balding dermal papilla cells

Project description:Androgenetic alopecia (AGA, male patterned baldness) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. With the aim of elucidating genes involved in AGA pathogenesis, we cultured immortalised balding human dermal papilla cells (BAB) and immortalised non-balding human dermal papilla cells (BAN) in 3-dimensional culture format, and compared gene expression using RNA-seq between BAB and BAN cells.

2022-09-27 | GSE184866 | GEO

RNA-seq of 2D-culture balding and non-balding dermal papilla cells

Project description:Androgenetic alopecia (AGA, male patterned baldness) is a prevalent hair loss condition in males that develops due to the influence of androgens and genetic predisposition. With the aim of elucidating genes involved in AGA pathogenesis, we cultured immortalised balding human dermal papilla cells (BAB) and immortalised non-balding human dermal papilla cells (BAN) in 2-dimensional culture format, and compared gene expression using RNA-seq between BAB and BAN cells.

2022-09-27 | GSE184501 | GEO

Transcriptome analysis reveals differences in vasculature signalling between human dermal papilla cells from balding and non-balding scalp

Project description:Transcriptome analysis of hTERT-immortalized balding (BAB) and non-balding (BAN) dermal papilla cells derived from frontal and occipital scalp of male patients with androgenetic alopecia Hamilton grade IV. Interrogation of transcriptome differences between BAB and BAN after dihydrotestosterone (DHT, active metabolite of androgen) treatment revealed significant enrichment of vasculature-related genes among down-regulated genes in BAB compared to BAN.

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Project description:RNA-seq of 2D-culture balding and non-balding dermal papilla cells

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Project description:Transcriptome analysis reveals differences in vasculature signalling between human dermal papilla cells from balding and non-balding scalp

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Spatial transcriptome reveals disturbance of peri-infundibular immune infiltration in androgenetic alopecia

Project description:Several studies have suggested that in addition to androgen-sensitive dermal papilla cells, peri-infundibular immune infiltration is associated with the balding process in androgenetic alopecia (AGA). Nevertheless, investigations into the molecular signatures of this compartments are limited because none of the current techniques enable high-throughput profiling of specific pathological areas.

2023-08-11 | GSE240637 | GEO

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