Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human gut metagenome

ABSTRACT: preterm infant gut metagenomes (S2_2013 and NIHY2_2012 cohorts)

PROVIDER: PRJNA376566 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5405610_1.fastq.gz	Fastqsanger.gz
	SRR5405610_2.fastq.gz	Fastqsanger.gz
	SRR5405620_1.fastq.gz	Fastqsanger.gz
	SRR5405620_2.fastq.gz	Fastqsanger.gz
	SRR5405630_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 812

Similar Datasets

human gut metagenome

Project description:preterm infant gut metagenomes (NIH Y4 Cohort)

| PRJNA396794 | ENA

Metaproteome of preterm infant gut microbiome

Project description:91 preterm infant gut metaproteomes measured in technical duplicate using an eleven salt pulse 2D-LC-MS/MS method. Samples represent 17 preterm infants over the first several weeks of life, of which 6 preterm infants eventually developed necrotizing enterocolitis.

| MSV000086096 | MassIVE

human gut metagenome

Project description:Metagenomics of preterm infant stool

| PRJNA799247 | ENA

Genome-resolved metaproteomic characterization of preterm infant gut microbiota development reveals core metabolic functions and variability during early-life

Project description:An integrated metagenomics and metaproteomics investigation of human preterm infant gut microbiota.

2017-02-23 | MSV000080565 | MassIVE

Relating human gut metagenome and metaproteome

Project description:Gut microbiome research is rapidly moving towards the functional characterization of the microbiota by means of shotgun meta-omics. Here, we selected a cohort of healthy subjects from an indigenous and monitored Sardinian population to analyze their gut microbiota using both shotgun metagenomics and shotgun metaproteomics. We found a considerable divergence between genetic potential and functional activity of the human healthy gut microbiota, in spite of a quite comparable taxonomic structure revealed by the two approaches. Investigation of inter-individual variability of taxonomic features revealed Bacteroides and Akkermansia as remarkably conserved and variable in abundance within the population, respectively. Firmicutes-driven butyrogenesis (mainly due to Faecalibacterium spp.) was shown to be the functional activity with the higher expression rate and the lower inter-individual variability in the study cohort, highlighting the key importance of the biosynthesis of this microbial by-product for the gut homeostasis. The taxon-specific contribution to functional activities and metabolic tasks was also examined, giving insights into the peculiar role of several gut microbiota members in carbohydrate metabolism (including polysaccharide degradation, glycan transport, glycolysis and short-chain fatty acid production). In conclusion, our results provide useful indications regarding the main functions actively exerted by the gut microbiota members of a healthy human cohort, and support metaproteomics as a valuable approach to investigate the functional role of the gut microbiota in health and disease.

2017-07-19 | PXD005780 | Pride

Project description:preterm infant gut metagenomes (NIH Y5 Cohort)

| PRJNA417343 | ENA

human gut metagenome

Project description:Infant Gut Development

| PRJNA269305 | ENA

Metaproteomics of Premature Infant Gut Colonization

Project description:Microbial colonization of the human gastrointestinal tract plays an important role in establishing health and homeostasis. However, the time-dependent and related functional signatures of microbial and human proteins during early colonization of the gut have yet to be determined. Thus, we employed shotgun proteomics via nano-2D-LC-MS/MS to simultaneously monitor microbial and human proteins in fecal samples from a healthy preterm infant during early development. ). All MS/MS spectra were searched against a predicted protein database containing 25 microbial species along with the Human RefSeq2011 genome using the SEQUEST algorithm (Eng et al, 1994), and filtered with DTASelect version 1.9 (Tabb et al, 2002) at the peptide level with standard filters [SEQUEST Xcorrs of at least 1.8 (+1), 2.5 (+2) 3.5 (+3)] organizing identified peptides to their corresponding protein sequences. This study provides the first elucidation of coordinated human and microbial proteins in the infant gut during early development.

2014-12-16 | PXD000114 | Pride

human gut metagenome

Project description:Human infant gut metagenome, infant shotgun sequencing

| PRJNA489090 | ENA

human gut metagenome

Project description:Premature infant gut Metagenome

| PRJNA215102 | ENA