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Microarray measuring gene expression in livers of DO mice

ABSTRACT: Microarray measuring gene expression in livers of DO mice

OTHER RELATED OMICS DATASETS IN: GSE99558GSE99561

PROVIDER: PRJNA388958 | ENA |

REPOSITORIES: ENA

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Microarray measuring gene expression in livers of DO mice

Project description:Genetic variation, in addition to environmental influences like diet, can govern the expression levels of microRNAs (miRNAs). MiRNAs are commonly found to operate cooperatively in groups to regulate gene expression. To investigate this, we combined small RNA sequencing, clinical phenotypes, and microarray data measuring gene expression from an outbred mouse model, the Diversity Outbred population. In the DO population, each individual has a distinct genome that is a mosaic of 8 inbred founder strains. We used these data to identify co-regulated modules of miRNAs and genes that are influenced by genetics and diet, and identify relationships between the modules and phenotypes in over 200 DO mice.

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