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Expression data from retinoic acid-induced differentiation of human embryonic stem cells (hESCs)

ABSTRACT: Expression data from retinoic acid-induced differentiation of human embryonic stem cells (hESCs)

PROVIDER: PRJNA412209 | ENA |

REPOSITORIES: ENA

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Expression data from retinoic acid-induced differentiation of human embryonic stem cells (hESCs)

Project description:Human embryonic stem cells (hESCs) display a unique ability to self-renew in culture while retaining the potential to form the full repertoire of cell types found in the body. A complex molecular network underlies the maintenance of this pluripotent state. We used microarrays to identify genes that are highly expressed in pluripotent hESCs, but are consequently down-regulated upon differentiation in the presence of retinoic acid.

2017-09-27 | GSE104173 | GEO

Gene expression in human embryonic stem cells (hESCs) upon the differentiation to neural lineages by timed delivery of retinoic acid

Project description:We report gene-expression profiling of hESCs differentiating to neuronal lineages upon the treatment with Retinoic Acid and Smoothened Agonisnt. We study weather RA patterning activity relies on duration of RA exposure and can be used to direct differentiation of hESCs into distinct neuronal cell types.

2020-08-31 | GSE147404 | GEO

MicroRNA profiling of mouse embryonic stem cells during retinoic acid-induced differentiation

Project description:Changes in microRNA expression profile during retinoic acid-induced differentiation of mouse embryonic stem cells.

2007-04-01 | E-MEXP-977 | biostudies-arrayexpress

CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation

Project description:Our data demonstrate that CARM1 is required for transcriptional activation of a subset of retinoic acid (RA) target genes in J1 murine embryonic stem cells

2018-12-26 | GSE115818 | GEO

Pluripotent mouse Embryonic Stem Cells and during Retinoic Acid-induced differentiation

Project description:Pluripotent mouse Embryonic Stem Cells and during Retinoic Acid-induced differentiation

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Gene expression in human embryonic stem cells (hESCs) upon the differentiation to neural lineages by timed delivery of retinoic acid

Project description:Gene expression in human embryonic stem cells (hESCs) upon the differentiation to neural lineages by timed delivery of retinoic acid

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Murine embryonic stem cells synthesize retinoic acid to promote their own spontaneous differentiation

Project description:Embryonic stem cells (ESC) are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass in their developmental potential. ESCs pluripotency is maintained through a complex interplay of different signaling pathways and a network of transcription factors, which is centered around Oct3/4, Sox2 and Nanog. Although, in general, much is known about this pluripotency self-renewal circuitry, the molecular events that lead ESC to exit from pluripotency and begin differentiation are currently less known. Retinoic acid, an active metabolite of the vitamin A (retinol), plays important and pleiotropic roles in vertebrate embryonic development and ESC differentiation. Here we demonstrate that RA promotes early steps of ESC differentiation, and that ESC increase their capacity to synthesize RA during spontaneous differentiation as embryoid bodies, up-regulating the RA biosynthetic pathway components RDH1, RDH10, ADH3, RALDH2, and CRABP2. Microarray derived from total RNA of mESC not treated or treated with all-trans retinoic acid (ATRA) for 2 hours.

2016-02-10 | E-GEOD-66043 | biostudies-arrayexpress

Retinoic acid dependent spermatogonial differentiation in mice

Project description:Retinoic acid dependent spermatogonial differentiation in mice

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Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells

Project description:All-trans retinoic acid (ATRA) alters gene expression in CCE WT embryonic stem cells, but has no effect on gene expression in RAR-deficient TKO cells (devoid of Retinoic Acid Receptors α, β, and γ)

2018-05-25 | GSE112412 | GEO

Retinoic acid signaling targets within the embryonic zebrafish eye during photoreceptor differentiation

Project description:The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. The purpose of this study was to identify eye-specific genes controlled by RA during photoreceptor differentiation in the zebrafish.

2015-08-28 | GSE63873 | GEO

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