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Expression data from mdx mice at 5 day, 2 weeks, 3 weeks, and 6 weeks

ABSTRACT: Expression data from mdx mice at 5 day, 2 weeks, 3 weeks, and 6 weeks

PROVIDER: PRJNA414232 | ENA |

REPOSITORIES: ENA

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Expression data from mdx mice at 5 day, 2 weeks, 3 weeks, and 6 weeks

Project description:We used microarrays to identify molecular pathways that define different disease stages and contribute to disease progression in the mdx mouse

2021-12-31 | GSE104959 | GEO

Time-course of mdx and wild type mice

Project description:Time-course microarray data set of mdx and wild type mice ranging from 1-20 weeks of age Keywords: time-course

2004-12-20 | GSE1574 | GEO

Transcriptomics of heart and muscle tissues of transgenic or mdx mice (DMD disease model) with UAA incorporation systems

Project description:We constructed the trans/mdx mice as a novel DMD disease model by crossing transgenic mice and mdx mice. The transgenic and trans/mdx mice have UAA incorporation system that can readthrough the nonsense mutation in the dmd gene with additional UAA. The whole transcriptomics of heart and muscle tissues of 5 mouse groups (n=2) were used to determine whether the introduced UAA incorporation system affect the normal gene expression of mice, or the safety of the system. Groups include: a) wild-type C57BL/6N mice; b) transgenic mice; c) mdx mice; d) trans/mdx mice without UAA; e) trans/mdx mice with UAA (50 mg NAEK every 2-3 day, treated for 4 weeks). The total numbers of expressed genes were around 11,000 in all 5 mouse groups. The expression levels of major genes (logFPKM>0) in 5 mouse groups were also close to each other. These data indicated that the UAA incorporation system was safe and could serve as a potential therapeutic strategy for DMD disease. The transgenic mice with UAA incorporation system we constructed could also cross with other nonsense mutation mice to build more functional animal models.

2020-10-03 | GSE158961 | GEO

Transcriptome profiling of muscle from control, mdx and Sirt6 knockout on mdx background mice

Project description:In this study, Pax7-Cre mediated inactivation of Sirt6 in mdx mice resulted in profound improvement of the mdx phenotype at the functional level. To study the underlying molecular mechanisms we performed RNA-seq of muscles from control, mdx and Sirt6mKO/mdx mice.

2022-05-12 | GSE168984 | GEO

Expression data from quadriceps of myofiber mineralocorticoid receptor conditional knockout (MRcko)/mdx and myeloid cell MRcko/mdx mice compared to Cre-/mdx control mice

Project description:To identify the gene expression differences in skeletal muscles resulting from conditional knockout of the mineralocorticoid receptor in myofibers and myeloid cells in dystrophin-deficient mdx mice

2024-04-03 | GSE244569 | GEO

Time-course of mdx and wild type mice

Project description:Time-course microarray data set of mdx and wild type mice ranging from 1-20 weeks of age Keywords: time-course

2010-05-27 | E-GEOD-1574 | biostudies-arrayexpress

Transcriptome profiling of muscle stem cells from control, mdx and Sirt6 knockout on mdx background mice

2022-05-12 | GSE168983 | GEO

Expression data from quadriceps of myofiber mineralocorticoid receptor conditional knockout (MRcko)/mdx and myeloid cell MRcko/mdx mice compared to Cre-/mdx control mice

Project description:Expression data from quadriceps of myofiber mineralocorticoid receptor conditional knockout (MRcko)/mdx and myeloid cell MRcko/mdx mice compared to Cre-/mdx control mice

| PRJNA1023586 | ENA

Gene expression profiles using microarrays in mdx and mdx/MMP-2-/- mice at 1 and 3 months of age

Project description:Matrix metalloprotease (MMP) -2 has been reported to be up-regulated in skeletal muscle in the lethal X-linked muscle disorder Duchenne muscular dystrophy (DMD), which is caused by loss of dystrophin. However, the role of MMP-2 in dystrophin-deficient muscle is not well known. The aim of this study was to verify the role of MMP-2 in dystrophin-deficient muscle by using mdx mice with genetic ablation of MMP-2 (mdx/MMP-2-/-). Gene expression profiles were analyzed in the skeletal muscle of mdx and mdx/MMP-2-/- mice at 1 and 3 months of age.

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A multigene analysis of the effects of L-arginine treatment in the hindlimb and diaphragm muscles of mdx mice.

Project description:Diaphragm and hindlimb muscle samples from BL10 or MDX mice treated with L-arginine or untreated. Ages 3/5/9/12 weeks are represented in analysis. Keywords = Muscular dystrophy Keywords = mdx Keywords = DNA microarrays Keywords = L-arginine Keywords = gene expression profiling Keywords: other

2004-08-10 | GSE1636 | GEO

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