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Expression data from human bone marrow derived mesenchymal stem cells (BMSCs) either cultured alone or co-cultured with human colon cancer cells HT29 or HCT116 respectively

ABSTRACT: Expression data from human bone marrow derived mesenchymal stem cells (BMSCs) either cultured alone or co-cultured with human colon cancer cells HT29 or HCT116 respectively

PROVIDER: PRJNA416308 | ENA |

REPOSITORIES: ENA

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Expression data from human bone marrow derived mesenchymal stem cells (BMSCs) either cultured alone or co-cultured with human colon cancer cells HT29 or HCT116 respectively

Project description:The cross-talk between mesenchymal stem cells (MSCs) and cancer cells remains controversial. It is imperative to understand how MSC and tumor cells communicate with each other and whether the MSC responds to the tumor according to its stage of progression. We used microarrays to detail the global programme of gene expression in human BMSCs either cultured alone or co-cultured with colon cancer cells HT29 or HCT116 respectively

2017-10-31 | GSE106325 | GEO

Gene expression profiles of Setd2 fl/fl BMSCs infected with lentivirus expressing GFP and Cre respectively

Project description:During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined osteogenesis accompanied by excess adipogenesis, which will lead to osteoporosis. Here we report that the H3K36 trimethylation, catalyzed by histone methyltransferase SETD2 regulates lineage commitment of BMSCs. Deletion of Setd2 in mBMSCs, through conditional Cre expression driven by Prx1 promoter, resulted in bone loss and marrow adiposity. Loss of Setd2 in BMSCs in vitro facilitated differentiation propensity to adipocytes rather than to osteoblasts. Through conjoint analysis of RNA-seq and ChIP-seq data, we identified a SETD2 functional target gene, Lbp, on which H3K36me3 was enriched, and its expression was affected by Setd2 deficiency. Furthermore, overexpression of LBP could partially rescue the lack of osteogenesis and enhanced adipogenesis resulted from the absence of Setd2 in BMSCs. Further mechanism study demonstrated that the trimethylation level of H3K36 could regulate Lbp transcriptional initiation and elongation. These findings suggest that H3K36 trimethylation mediated by SETD2 could regulate the cell fate of mesenchymal stem cells in vitro and in vivo, indicating that the regulation of H3K36me3 level by targeting SETD2 and/or the administration of downstream LBP protein may represent potential therapeutic way for new treatment in metabolic bone diseases, such as osteoporosis.

2018-11-08 | GSE120244 | GEO

Gene expression profiles of Setd2 fl/fl BMSCs infected with lentivirus expressing GFP and Cre respectively

Project description:Gene expression profiles of Setd2 fl/fl BMSCs infected with lentivirus expressing GFP and Cre respectively

| PRJNA492290 | ENA

RNAseq for cultured Control and TgAPPsweOCN BMSCs (sorted Ai9+ Osteoblast-linage cells)

Project description:RNAseq for cultured Control and TgAPPsweOCN BMSCs (sorted Ai9+ Osteoblast-linage cells)

| PRJNA776261 | ENA

miRNA profiling of EV71 infected HT29 cells

Project description:HT29 cells was infected with EV71 at MOI 1 or nil respectively and harvested at 36hpi We use miRNA microarray to profile and identify miRNA which are up or down regulated due to EV71 infection

2014-05-08 | GSE57372 | GEO

Long RNA in endothelial cells and EVs cultured alone or with tumor cells

Project description:RNA was harvested from endothelial cells cultured alone or with tumor cells and the associated endothelial extracellular vesicles.

2022-03-10 | GSE164869 | GEO

Small RNA in endothelial cells and EVs cultured alone or with tumor cells

Project description:RNA was harvested from endothelial cells cultured alone or with tumor cells and the associated endothelial extracellular vesicles.

2022-05-13 | GSE167751 | GEO

RNA stearic HT29

Project description:RNA stearic HT29

| PRJEB79772 | ENA

HT29 and GATA6

Project description:HT29 and GATA6

| PRJNA263819 | ENA

Expression data from young and aged BMSCs

Project description:Bone marrow mesenchymal stem cells (BMSCs) differentiate into various mature cell types, including adipocytes and osteoblasts, which is determined by genetic, molecular mediators and local microenvironment. With age, BMSCs become inclined to undergo differentiation into adipocytes rather than osteoblasts, resulting in an increased number of adipocytes and a decreased number of osteoblasts, causing osteoporosis. The dysregulated the gene expression in BMSCs during aging were analyzed. We used microarrays to detail the global programme of gene expression duing aing in BMSCs.

2018-08-15 | GSE116925 | GEO

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