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Expression data from AMPKalpha1/2-double knockout murine embryonic fibroblasts stimulated or not with AICAR

ABSTRACT: Expression data from AMPKalpha1/2-double knockout murine embryonic fibroblasts stimulated or not with AICAR

PROVIDER: PRJNA416925 | ENA |

REPOSITORIES: ENA

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Expression data from AMPKalpha1/2-double knockout murine embryonic fibroblasts stimulated or not with AICAR

Project description:AICAR is a metabolite with anti-tumoral properties. Its monophosphate derivative ZMP is an AMP mimetic activator of the protein kinases AMPK. However, AICAR also mediates AMPK-independent effects. A kinetic transcriptome analysis was therefore carried out in Ampkα1/α2 double knockout murine embryonic fibroblasts in response to AICAR in order to unveil these AMPK-independent functions,

2018-05-31 | GSE106460 | GEO

Expression data of stimulated murine primary lung fibroblasts

Project description:Expression data of stimulated murine primary lung fibroblasts

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Effect of AICAR monophosphate and AICAr riboside accumulation on global transcription

Project description:AICAR monophosphate (5-Aminoimidazole-4-carboxamide ribonucleotide) is a metabolic intermediate of the de novo purine synthesis pathway presenting highly promising metabolic and antiproliferative properties. Yeast mutants accumulating AICAR are auxotroph for histidine. A screening for suppressors of this phenotype identified recessive and dominant mutants that result in lowering intracellular AICAR concentration. The recessive mutants affect adenosine kinase which is shown here to catalyze the phosphorylation of AICAR riboside in yeast. The dominant mutants strongly enhance the capacity of the alkaline phosphatase Pho13p to dephosphorylate succinyl-AICAR monophosphate into the non-toxic riboside form. By combining these mutants to transcriptomic and metabolomic analyses, we establish that in yeast both toxic and physiological responses to AICAR are linked to the concentration of the monophosphate form, while the nucleoside moiety has no effect even at high concentration. Finally, we establish that (S)AICAR concentration varies under physiological conditions, thus modulating transcriptional regulation of purine pathway genes. This SuperSeries is composed of the SubSeries listed below.

2011-07-11 | GSE29324 | GEO

Effect of Metformin and AICAR treatments in the prostate cancer cell line LNCaP

Project description:Transcriptional profiling of human prostate cancer cell line LNCaP treated with Metformin or AICAR compared to control non-stimulated LNCaP.

2017-08-11 | GSE83673 | GEO

Mechanisms of AICAR in lung cancer

Project description:The purpose of the research is to delineate the mechanism behind AICAR-induced cytotoxicity by understanding the genetic pathways that are affected with AICAR treatment.

2023-02-21 | GSE198777 | GEO

AICAR regulate IEGs expression in ALL cells

Project description:To identify genes transcriptionally regulated by AICAR under cellular stress, We treated NALM6 cells for 45 min with vehicle (DMSO) or AICAR (15 mM), and examined their RNA profile using RNA-Seq. The immediate early genes (IEGs) were identified as a subset of genes downregulated by AICAR.

2021-07-22 | GSE152917 | GEO

Expression data from Daudi cells stimulated with anti-CD40 and/or IL-4 for 6 hr with or without AICAR-pretreatment

Project description:We used microarrays to detail the action of AICAR on the transcriptome response to CD40-ligation and IL-4 stimulation in Daudi cells. Keywords: gene expression array-based, response to anti-CD40 and/or IL-4 with or without AICAR

2006-07-31 | GSE4812 | GEO

Gene expression in murine embryonic fibroblasts stimulated with DNA or LPS

Project description:Gene expression in murine embryonic fibroblasts stimulated with DNA or LPS

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Transcriptional profiling of long-term stimulated primary murine intestinal fibroblasts with interleukin-36.

Project description:Previous stimulation experiments of stimulated primary murine colonic fibroblasts with IL-36R ligands for 4h in vitro showed an upregulation of pro-inflammatory cytokines e.g. IL-6, IL-1b and chemokines e.g. CXCL1, CCL2 indicating an important role for IL-36 in inflammation. We were interested in analyzing long-term stimulation (9 days) of intestinal fibroblasts to identify a putative differential expression profile. The experimental setup included 6 samples from 3 colons in a pairwise design (3 stimulated vs 3 unstimulated).

2018-11-19 | E-MTAB-6476 | biostudies-arrayexpress

RNA-seq of U937 cells treated with AICAr

Project description:U937 cells were treated wth 0.2 mM AICAr for 24 h to compare the results on cell line know to differentiate in the presence of AICAr with the results on primary patient sample.

2020-11-15 | E-MTAB-9537 | biostudies-arrayexpress

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