Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Molecular Epidemiology of Antibiotic Resistant ESKAPE Pathogens Isolated from Public Sector Hospitals in uMgungundlovu District, KwaZulu-Natal, South Africa Genome sequencing and assembly

PROVIDER: PRJNA417366 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	PGCR01.dat.gz	Other
	PGCR01.fasta.gz	Fasta.gz
	PGCR01.master.dat	Other
	PGCS01.dat.gz	Other
	PGCS01.fasta.gz	Fasta.gz

Items per page:

1 - 5 of 44

Similar Datasets

Project description:Antibiotic resistance in Enterobacteriaceae from water sources in uMgungundlovu District, KwaZulu-Natal, South Africa

| PRJNA609073 | ENA

Project description:Antibiotic resistance in Enterococcus species from water sources in uMgungundlovu District, KwaZulu-Natal, South Africa

| PRJNA609064 | ENA

Mycobacterium tuberculosis

Project description:Whole genome sequencing of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa

| PRJNA559528 | ENA

Bacteria

Project description:Genomic Epidemiology of Antibiotic-Resistant Bacteria from Agricultural Soil Fertilized with Poultry Manure in KwaZulu Natal, South Africa

| PRJNA609650 | ENA

prokaryotic metagenome

Project description:Genome sequence data of multidrug-resistant ESKAPE pathogens in Vietnamese hospitals

| PRJNA857185 | ENA

Enterobacteriaceae

Project description:One Health Approach for Carbapenem resistant Enterobacteriaceae in KwaZulu-Natal, South Africa

| PRJNA564235 | ENA

Acinetobacter, Klebsiella, Pseudomonas, Enterobacter

Project description:MDR ESKAPE pathogens

| PRJNA411997 | ENA

Kinase Selectivity Profiling of anti-MRSA Diarylimidazoles in HEK293 Cells

Project description:Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a small array of diarylimidazoles was screened against the ESKAPE pathogens and the results made publicly available through the Open Source Antibiotics (OSA) consortium. Of the 18 compounds tested (at 32 μg/mL), 15 showed >90% growth inhibition activity against MRSA alone. In the subsequent hit-to-lead optimization of this chemotype, 147 new heterocyclic compounds containing the diarylimidazole and other core motifs were synthesized, tested against MRSA and structure-activity relationships identified. While potent, these compounds have moderate to high clearance rates and some associated toxicity. The best overall balance of parameters was found with OSA_975, a compound with good potency and solubility and slow clearance in rat hepatocytes. In this study, we used multiplexed kinase inhibitor beads/mass spectrometry (MIB/MS) to study the human molecular targets of these phenotypically active compounds.

2024-01-26 | PXD040208 | Pride

Evolution and epidemiology of ESKAPE pathogens in the Kingdom of Saudi Arabia

Project description:Evolution and epidemiology of ESKAPE pathogens in the Kingdom of Saudi Arabia

| PRJEB66182 | ENA

Project description:Evolution and epidemiology of ESKAPE pathogens in the Kingdom of Saudi Arabia

| PRJNA1018815 | ENA