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Derivation of kidney organoids from human pluripotent stem cells [RNA-Seq: Data Set 2]

ABSTRACT: Derivation of kidney organoids from human pluripotent stem cells [RNA-Seq: Data Set 2]

PROVIDER: PRJNA423254 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6396840_1.fastq.gz	Fastqsanger.gz
	SRR6396840_2.fastq.gz	Fastqsanger.gz
	SRR6396850_1.fastq.gz	Fastqsanger.gz
	SRR6396850_2.fastq.gz	Fastqsanger.gz
	SRR6396841_1.fastq.gz	Fastqsanger.gz

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Derivation of kidney organoids from human pluripotent stem cells [RNA-Seq: Data Set 1]

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Derivation of kidney organoids from human pluripotent stem cells [RNA-Seq: Data Set 2]

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Proteomic analysis of induced pluripotent stem cell-derived kidney organoids

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Project description:Hepatocyte nuclear factor 1B (HNF1B) encodes a transcription factor expressed in developing human kidney epithelia. Heterozygous HNF1B mutations are the commonest monogenic cause of dysplastic kidney malformations (DKMs). To understand their pathobiology, we generated heterozygous HNF1B mutant kidney organoids from CRISPR-Cas9 gene-edited human ESCs and iPSCs reprogrammed from a family with HNF1B-asscociated DKMs. Mutant organoids contained enlarged malformed tubules and displayed deregulated cell turnover. This submission is RNAseq of organoids from MAN13 embryonic stem cells.

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MODELLING GENETIC POLYCYSTIC KIDNEY DISEASE USING HUMAN PLURIPOTENT STEM CELL- DERIVED KIDNEY ORGANOIDS

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kidney organoids derived from human induced pluripotent stem cells (iPSC)

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