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Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

ABSTRACT: Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

PROVIDER: PRJNA434461 | ENA |

REPOSITORIES: ENA

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Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

Project description:The histone demethylase LSD1 is a key chromatin regulator that plays a crucial role in development. It has been shown to act both as a co-repressor and a co-activator of genes expression and to affect the expression of many genes important for development. In Drosophila, dLsd1 is essential for oogenesis; however, our current knowledge of dLsd1 function is insufficient to explain its precise role in the ovary. To better define the role of dLsd1 in oogenesis, we performed genome-wide analysis of dLsd1 binding in the ovary by Chromatin Immunoprecipitation followed by sequencing (ChIP-Seq).

2019-02-08 | GSE110331 | GEO

Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

Project description:Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

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Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

Project description:To study the effect of dLsd1 knockdown on gene expression in oogenesis, we performed transcripts profiling by microarray in wild type ovaries and ovaries depleted for dLsd1.

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A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.

Project description:The histone demethylase LSD1 is a key chromatin regulator that is often deregulated in cancer. Its ortholog, dLsd1 plays a crucial role in Drosophila oogenesis; however, our knowledge of dLsd1 function is insufficient to explain its role in the ovary. Here, we have performed genome-wide analysis of dLsd1 binding in the ovary, and we document that dLsd1 is preferentially associated to the transcription start site of developmental genes. We uncovered an unanticipated interplay between dLsd1 and the GATA transcription factor Serpent and we report an unexpected role for Serpent in oogenesis. Besides, our transcriptomic data show that reducing dLsd1 levels results in ectopic transposable elements (TE) expression correlated with changes in H3K4me2 and H3K9me2 at TE loci. In addition, our results suggest that dLsd1 is required for Piwi dependent TE silencing. Hence, we propose that dLsd1 plays crucial roles in establishing specific gene expression programs and in repressing transposons during oogenesis.

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