Project description:In dogs, a species for which markers of cell populations are often limiting, we sought to evaluate in an unbiased way the heterogeneity of cell subpopulations in the bronchoalveolar lavage fluid of healthy dogs, by single-cell RNA-sequencing.

2020-06-29 | E-MTAB-9265 | biostudies-arrayexpress

Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid

Project description:Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid

| PRJNA1068661 | ENA

Bronchoalveolar lavage fluid from a severe pneumonia patient

Project description:raw sequencing reads of bronchoalveolar lavage fluid from a severe pneumonia patient

| PRJNA813338 | ENA

Rat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures

Project description:Label free quantitative proteomics of bronchoalveolar lavage (BAL) fluid collected from rats exposed to e-cigarette aerosols (humidified air control, PG/VG, PG/VG + Nicotine, or PG/VG + Nicotine + Vanillin)

2023-01-06 | MSV000091015 | MassIVE

Bronchoalveolar lavage fluid and blood from human lung transplant recipients

Project description:Bronchoalveolar lavage fluid and blood from human lung transplant recipients Metagenome

| PRJNA764588 | ENA

Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid

Project description:Many lung diseases remain understudied due to a lack of experimental models. Lung organoids, which consist of self-organizing epithelial cells, provide versatile in vitro models for normal and abnormal biology, drug screening, gene editing, and personalized therapeutics. However, human organoids are generally derived from lung tissue, which is not commonly obtained and represents only a small fraction of lung pathologies. Induced pluripotent stem cells have provided an important alternative but require complex manipulation. Recently, one study reported airway organoids from bronchoalveolar lavage (BAL) fluid, though sample sizes and characterization were limited. Here, we demonstrate robust establishment of airway organoids from a variety of human BAL samples and show that these organoids consist predominantly of basal cells plus differentiated airway cell types including secretory, ciliated, KRT13+ “hillock,” and ionocyte cells. Furthermore, we report the development of BAL-derived alveolar organoids comprised of alveolar type 2 (AT2) cells. These techniques significantly expand the scope of lung diseases that can be studied using safely accessible primary human cells.

2024-05-01 | GSE254166 | GEO

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