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ABSTRACT: Transient and permanent gene expression changes during high temperature-induced masculinization in Nile tilapia brain

PROVIDER: PRJNA449132 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6957080_1.fastq.gz	Fastqsanger.gz
	SRR6957080_2.fastq.gz	Fastqsanger.gz
	SRR6957090_1.fastq.gz	Fastqsanger.gz
	SRR6957090_2.fastq.gz	Fastqsanger.gz
	SRR6957081_1.fastq.gz	Fastqsanger.gz

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Global DNA methylation changes in Nile tilapia gonad during high-temperature induced masculinization

Project description:In fish, the sex determining mechanisms can broadly be classified as genotypic (GSD), temperature-dependent (TSD), or genotypic plus temperature effects (GSD+TE). For the fish species with TSD or GSD+TE, extremely high or low temperature can affect its sex determination and differentiation. For long time, the underlying changes in DNA methylation that occur during high or low temperature induced sex reversal have not been fully clarified. In this study, we used Nile tilapia as a model to perform a genome-wide survey of differences in DNA methylation in female and male gonads between control and high temperature induced groups using methylated DNA immunoprecipitation (MeDIP). We identified the high temperature induction-related differentially methylated regions (DMRs), and performed functional enrichment analysis for genes exhibiting DMR. These identified differentially methylated genes were potentially involved in the connection between environmental temperature and sex reversal in Nile tilapia. In this study, four samples (control females, CF; control males, CM; induced females, IF; induced males, IM) were analyzed.

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Global DNA methylation changes in Nile tilapia gonad during high-temperature induced masculinization

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Project description:Integrated analysis of DNA methylome and RNA transcriptome during high-temperature-induced masculinization in sex-undifferentiated Nile tilapia gonad

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Project description:We report an association of DNA hydroxymethylation profiling at single nucleotide resolution with gene expression in the fast muscle of Nile tilapia.

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Oxytocin Signaling Regulates the Homeostatic Response to Cold Stress in Ectothermic Vertebrate

Project description:Homeothermic vertebrates exposed to low temperature challenge activate multiple central and physiological pathways in order to regain homeostatic balance within the new environmental constrains. Such homeostatic responses include shivering and non-shivering thermogenesis, altered carbohydrate and lipid metabolism and protein catabolism synchronized by neuroendocrine responses. Pending their evolutionary life history, some of these physiological responses were also identified in poikilothermic vertebrates, yet a conception of heat seeking behavior and lack of cold-related metabolic regulation prevails. Using various physiological parameters and hypothalamic transcriptome analysis in the tropical poikilotherm Nile tilapia, we now demonstrate that cold stress in a poikilotherm induce complex central and physiological homeostatic responses. We further show that oxytocin which is a known thermoregulator in homeotherms, actively regulates temperature related homeostasis in poikilotherms. Moreover, we show that pharmacological or genetic blockage of oxytocin signaling affects oxygen-dependent metabolic rate in two cold exposed poikilothermic models. Therefore, our study identifies oxytocin as an adaptive and evolutionarily conserved metabolic regulator and show that poikilotherms brain actively respond to cold temperature stress by regulating metabolic physiology.

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