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Exosomal miRNAs released by neural stem/progenitor cells versus astrocytes

ABSTRACT: Exosomal miRNAs released by neural stem/progenitor cells versus astrocytes

PROVIDER: PRJNA450994 | ENA |

REPOSITORIES: ENA

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Exosomal miRNAs released by neural stem/progenitor cells versus astrocytes

Project description:An Affymetrix microRNA (miRNA) Array was used to compare exosomal miRNAs released by hypothalamic stem/progenitor cells (htNSC), hippocampal NSC (hippoNSC) and astrocytes in primary culture. This assay is to provide preliminary information on the general profile of exosomal miRNAs released by these cells, while to study any particular miRNA species should require further quantitative analyses such as qPCR based on enough sample sizes.

2018-04-20 | GSE113383 | GEO

Microarray analysis of exosomal miRNAs from different liver cancer cells

Project description:To explore how tumor-derived exosomes activate fibroblasts and foster lung metastasis of liver cancer. MiRNAs encapsulated in exosomes are abundant and play an important role in cell-cell communication. Therefore, we hypothesized that tumor-derived exosomal miRNAs mediate fibroblasts activation. To identify the specific miRNAs involved, we conducted microarrays to generate miRNAs profiles of exosomes derived from the four liver cancer cell lines with different migration and invasion abilities. CSQT-2 and HCC-LM3 cells were high metastatic cancer cells, versus to HepG2 and MHCC-97L cells. We divided them into the following groups: CSQT-2 versus HepG2 (with different origins), HCC-LM3 versus MHCC-97L (with the same origin) and compared the up-regulated miRNAs in both two high-metastatic cancer cells-derived exosomes. Then, these up-regulated miRNAs were subjected to validation to define the most important exosomal miRNAs in regulating fibroblast activation and contributing to lung metastasis of liver cancer.

2017-11-03 | GSE106452 | GEO

Exosomal miRNAs from serum sequencing

Project description:Exosomal miRNAs from serum sequencing

| PRJNA1100526 | ENA

Expression data of exosomal miRNAs extracted from serum

Project description:Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin Lymphoma with complex clinical symptoms. Currently, the diagnosis of DLBCL depends largely on pathologic analysis of biopsy tissue, which is an invasive procedure and often poses some risk to patients. Exosomal miRNAs have emerged as promising noninvasive biomarkers for detecting tumor or monitoring disease progress. We aim to investigate the potential of circulating exosomal miRNAs to assist with diagnosis of DLBCL.In the present research, we used the miRCURY LNA™ microRNA Array to investgate the profiles of differentially expressed miRNAs in the exosomes of peripheral blood serum. As a result, circulating exosomal miRNA profiling yielded a total of 332 differentially expressed miRNAs (157 with up-expression and 175 with down-expression) between the DLBCL patients and healthy controls.

2021-12-06 | GSE171272 | GEO

Role of Circulating Exosomal miRNAs in early diabetic retinopathy

Project description:To investigate the possibilities of circulating exosomal miRNAs in the early screening and prevention of diabetic retinopathy(DR), and to explore how the exosomal miRNAs functioning in DR. We then performed gene expression profiling analysis using data obtained from small RNA-seq of 3 diabetes mellitus(DM) patients and 3 DR patients.

2023-07-12 | GSE221535 | GEO

Expression data of exosomal miRNAs extracted from plasma [Affymetrix miRNA 4.0]

Project description:Exosomal miRNAs have emerged as promising disease biomarkers. We aim to investigate the potential of exosomal miRNAs to assist with AIS clinical diagnosis. In the present research, we used the Affymetrix Genechip miRNA 4.0 Array to investgate the profiles of differentially expressed miRNAs (DEMs) in the exosomes of peripheral blood plasma. As a result, exosomal miRNA profiling yielded a total of 05 DEMs between the AIS (Acute Ischemic Stroke) patients and controls.

2025-03-10 | GSE291442 | GEO

Analysis of exosomal miRNAs upon irradiation in pancreatic cancer cells

Project description:We used miRNA-seq and bioinformatics to analyze and annotate the expression profiles exosomal miRNAs in pancreatic cancer cells after radiation, compared with the unirradiated cells. A total of 481 miRNAs were identified, and 284 miRNAs were annotated in miRBase. There were 22 filtered differentially expressed miRNAs (9 for up-regulated and 13 for down-regulated, fold change > 2, p-value < 0.05). This study provides the results of exosomal miRNA change in pancreatic cancer cells after radiation.

2020-06-14 | GSE138983 | GEO

Expression data of exosomal miRNAs extracted from plasma [Affymetrix miRNA 4.0]

Project description:Tuberculosis (TB) is difficult to diagnose under complex clinical conditions. Exosomal miRNAs have emerged as promising disease biomarkers. We aim to investigate the potential of exosomal miRNAs to assist with TB clinical diagnosis. In the present research, we used the Affymetrix Genechip miRNA 4.0 Array to investgate the profiles of differentially expressed miRNAs (DEMs) in the exosomes of peripheral blood plasma. As a result, exosomal miRNA profiling yielded a total of 102 DEMs (98 with up-expression and 4 with down-expression) between the TB (pulmonary tuberculosis and tuberculosis meningitis) patients and controls.

2018-07-03 | GSE116542 | GEO

Plasma exosomal miRNAs microarray in polymicrobial sepsis

Project description:Plasma exosomal miRNAs microarray in polymicrobial sepsis

| PRJNA480304 | ENA

Profiling of exosomal miRNAs during maturation of 3T3-L1 adipocytes

Project description:We profiled miRNAs in 3T3-L1 adipocyte-secreted exosomes and our microarray analysis revealed that more than 300 exosomal miRNAs were detected during adipocyte differentiation.

2021-01-24 | GSE154875 | GEO

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