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Expression data from allergic patients to profilin

ABSTRACT: Expression data from allergic patients to profilin

PROVIDER: PRJNA472340 | ENA |

REPOSITORIES: ENA

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Expression data from allergic patients to profilin

2018-05-22 | GSE114707 | GEO

Metabolomic Analysis of plasma samples from Non-Allergic Subjects and Profilin-Allergic Patients overexposed to Grass Pollen

Project description:Prevalence and severity of allergic diseases have increased worldwide. To date, respiratory allergy phenotypes are not fully characterized and, along with inflammation progression, treatment is increasingly complex and expensive. Profilin sensitization constitutes a good model to study the progression of allergic inflammation. Our aim was to identify the underlying mechanisms and the associated biomarkers of this progression, focusing on severe phenotypes, using transcriptomics and metabolomics. Methods: 25 subjects were included in the study. Plasma samples were analyzed using Gas and Liquid Chromatography coupled to Mass Spectrometry (GC-MS and LC-MS, respectively). Individuals were classified in 4 groups – “non-allergic”, “mild”, “moderate” and “severe” – based on their clinical history, their response to an oral challenge test with profilin, and after a refinement using a mathematical metabolomic model. PBMCs were used for microarray analysis.

2018-06-13 | ST000980 | MetabolomicsWorkbench

Expression data from lymphocytes (CD3+ cells) from severe, mild allergic patients and a non allergic group.

Project description:Expression data from lymphocytes (CD3+ cells) from severe, mild allergic patients and a non allergic group.

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Expression data from lymphocytes (CD3+ cells) from severe, mild allergic patients and a non allergic group.

Project description:The causes underlyed the acquisition and maintainance of a severe allergic phenotype remain unknown. Here, we study the cd3+ complete transcriptomic fingerprint from severity-stratified patients to understand the involvement of these cells in the development of severe allergy. We used microarrays to detail the global programme of gene expression of CD3+ cells from severity-stratified allergic patients

2023-02-02 | GSE224253 | GEO

Expression data from OVA-induced allergic mice

Project description:Expression data from OVA-induced allergic mice

| PRJNA483728 | ENA

Expression data from OVA-induced allergic mice [Agilent]

Project description:Expression data from OVA-induced allergic mice [Agilent]

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Expression data from OVA-induced allergic mice [Affymetrix]

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The effects of novel adjuvant complex and CpG ODN on host immune response to recombinant Eimeria profilin vaccine

Project description:This study investigated the ability of two novel adjuvant formulations, QCDC (Quil A/cholesterol/DDA/Carbopol) and QCDCR (QCDC/Bay R1005), in combination with a recombinant profilin vaccine, to modulate host protective immunity and to alter new gene expression during experimental avian coccidiosis. Four-condition experiment, Profilin only vs. Non-vaccination, Profilin only vs. Co-vaccination of QCDC plus profilin, Profilin only vs. Co-vaccination of QCDCR plus profilin, Biological replicates: 2 profilin only replicates, 2 Non-vaccination replicates, 2 QCDC plus profilin replicates, 2 QCDCR plus profilin replicates with dye-switching.

2010-10-28 | E-GEOD-24966 | biostudies-arrayexpress

Global gene expression of nasal epithelial cells in patients with seasonal allergic rhinitis

Project description:Analysis of nasal epithelial cells from adult patients with seasonal allergic rhinitis and from non allergic controls. Results provide insight into the molecular mechanisms associated with inflammatory responses in nasal mucosa. Total RNA was obtained from nasal epithelial cells of 7 seasonal allergic rhinitis patients and 5 non-allergic control subjects

2015-01-16 | E-GEOD-43523 | biostudies-arrayexpress

Cancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1

Project description:Aberrant expression of nuclear transporters and altered subcellular localization of their cargo proteins are increasingly recognized as drivers and therapeutic targets of cancer. Here, we report that exportin-6, a nuclear exporter specific for actin/profilin-1, is upregulated in a broad range of cancers and associated with poor prognosis. Exportin-6 loss triggers antitumor effects in breast cancer cells in a profilin-1-dependent fashion. Nuclear profilin-1 interacts with the Super Elongation Complex (SEC), a positive transcriptional regulator of pro-cancer genes including MYC. Exportin-6 loss, by increasing nuclear profilin-1, inhibits SEC-dependent transcription and sensitizes breast cancer cells to inhibition of BET domain proteins. Thus, exportin-6 upregulation is a previously unrecognized cancer addiction that reduces the transcriptional inhibitory and anticancer activities of nuclear profilin-1.

2021-04-07 | GSE144372 | GEO

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