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Transcriptomics analysis of the livers of old mice treated with Ouabain

ABSTRACT: Transcriptomics analysis of the livers of old mice treated with Ouabain

PROVIDER: PRJNA503413 | ENA |

REPOSITORIES: ENA

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Transcriptomics analysis of the livers of old mice treated with Ouabain

Project description:Methods: Liver mRNA profiles of 7 weeks old wild-type (WT) and 24 months old mice treated with Vehicle or Ouabain (1mg/Kg)

2019-09-03 | GSE122080 | GEO

Comparing expression in livers of 1-month vs 6-month old mice

Project description:To look for age-related changes in the liver, we used RNAseq gene expression analysis to characterize mRNA expression profile in livers from 1-month vs. 6-month-old mice

2019-08-01 | GSE103069 | GEO

scRNA-seq of organoids derived from young and old mice livers

Project description:scRNA-seq of organoids derived from young and old mice livers

| PRJEB48427 | ENA

RNA Sequencing of livers from ApoE-/- mice treated with HIF1a inhibitor PX-478 or Saline

Project description:Purpose: HIF1a inhibitor PX-478 prevents hypercholesterolemia in ApoE-/- mice fed Western diet for 3 months. The goal of this study was to determine the mechanisms in the liver through which PX-478 regulates cholesterol. Methods: 4-week old ApoE-/- mice were fed a Western diet and injected intraperitoneally, bi-weekly with either PX-478 (40 mg/kg) or Saline for 3 months. The livers of 3 PX-478-treated mice and 4 Saline-treated mice were used for this RNA-seq study. Results: We identified 800+ differentially expressed genes in the PX-478-treated ApoE-/- mice livers relative to the saline-treated control livers. A subset of these genes were found to play important roles in cholesterol regulation and were further validated by qPCR analysis. Conclusions: Our study details potential hepatic cholesterol regulating mechanisms for HIF1a inhibitor PX-478. These results, coupled with our findings on the effect of PX-478 on two different mouse models of atherosclerosis, demonstrate that PX-478 is a potential anti-atherogenic and anti-hypercholesterolemic drug.

2022-02-18 | GSE179952 | GEO

Bulk RNA-seq of organoids derived from young and old mice livers

Project description:Bulk RNA-seq of organoids derived from young and old mice livers

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RNA-seq of livers from mice treated with/without iD1

Project description:RNA seq was perform to compare expression levels of mRNA in livers of mice treated with a vehicle and iD1.

2022-04-05 | GSE185851 | GEO

RNA-seq of livers from mice treated with/without iD1

Project description:RNA-seq of livers from mice treated with/without iD1

| PRJNA771002 | ENA

Gene expression data of livers from C57BL/6 treated with low dose tunicamycin

Project description:Sustained ER stress is tightly associated with hyperglycemia and type 2 diabetes.However, the molecular mechanisms remain largely unknown.In order to identify genes that are potentially involved in ER stress-associated hyperglycemia, transcriptomics analyses were performed using RNA-sequencing,which revealed that many genes were dys-regulated in the livers of mice treated with tunicamycin.

2019-11-18 | GSE135372 | GEO

Quantitative proteomic analysis of the livers from 5-week-old HyD-LIRflox/flox and HyD-LIRflox/flox; Alb-Cre mice.

Project description:We have previously shown that the HyD-LIR-Venus probe can specifically inhibit selective autophagy by suppressing the interaction of LIR-containing selective autophagy substrates and receptors with ATG8-family proteins in vivo. We generated hepatocyte-specific HyD-LIR-Venus-expressing mice (HyD-LIRflox/flox; Alb-Cre) by crossing HyD-LIRflox/flox mice, in which HyD-LIR-Venus is expressed under CAG promoter in a Cre-recombinase-dependent manner, with Alb-Cre transgenic mice that express Cre under the control of the Albumin promoter. We performed quantitative proteomic analysis of the livers of 5-week-old HyD-LIRflox/flox and HyD-LIRflox/flox; Alb-Cre mice using the RTS-SPS-MS3 method on Tribrid mass spectrometry.

2023-04-24 | PXD037013 | JPOST Repository

Comparing gene expression in livers of 1-month vs 6-month old mice following DEN treatment

Project description:To look for age-related changes in the liver that take place during DNA damage resolution, we used RNAseq gene expression analysis to characterize mRNA expression profile in livers from 1-month vs. 6-month-old mice either before or 2 days (representing the peak of DNA damage response) and 6 days (representing the resolution phase of DNA damage) after DEN treatment.

2018-09-01 | GSE103200 | GEO

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