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Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

ABSTRACT: Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

PROVIDER: PRJNA507018 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9735480_1.fastq.gz	Fastqsanger.gz
	SRR9735480_2.fastq.gz	Fastqsanger.gz
	SRR9735490_1.fastq.gz	Fastqsanger.gz
	SRR9735490_2.fastq.gz	Fastqsanger.gz
	SRR9735481_1.fastq.gz	Fastqsanger.gz

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Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

Project description:Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

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Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

Project description:The development of single-cell RNA-Sequencing (scRNA-Seq) has allowed high resolution analysis of cell type diversity and transcriptional networks controlling cell fate specification. To identify the transcriptional networks governing human retinal development, we performed scRNA-Seq over retinal organoid and in vivo retinal development, across 20 timepoints. Using both pseudotemporal and cross-species analyses, we examined the conservation of gene expression across retinal progenitor maturation and specification of all seven major retinal cell types. Furthermore, we examined gene expression differences between developing macula and periphery and between two distinct populations of horizontal cells. We also identify both shared and species-specific patterns of gene expression during human and mouse retinal development. Finally, we identify an unexpected role for ATOH7 expression in regulation of photoreceptor specification during late retinogenesis. These results provide a roadmap to future studies of human retinal development, and may help guide the design of cell-based therapies for treating retinal dystrophies.

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Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

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Project description:The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution analysis of cell-type diversity and transcriptional networks controlling cell-fate specification. To identify the transcriptional networks governing human retinal development, we performed scRNA-seq analysis on 16 time points from developing retina as well as four early stages of retinal organoid differentiation. We identified evolutionarily conserved patterns of gene expression during retinal progenitor maturation and specification of all seven major retinal cell types. Furthermore, we identified gene-expression differences between developing macula and periphery and between distinct populations of horizontal cells. We also identified species-specific patterns of gene expression during human and mouse retinal development. Finally, we identified an unexpected role for ATOH7 expression in regulation of photoreceptor specification during late retinogenesis. These results provide a roadmap to future studies of human retinal development and may help guide the design of cell-based therapies for treating retinal dystrophies.

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