Project description:Long-range enhancers play an important role in the temporal and spatial control of gene expression and are deregulated in many cancers. Yet, the mechanisms that govern enhancer activity during development and oncogenesis remain poorly understood. In this study we analyze the chromatin accesibility of mice T-ALL tumors.
Project description:Long-range enhancers play an important role in the temporal and spatial control of gene expression and are deregulated in many cancers. Yet, the mechanisms that govern enhancer activity during development and oncogenesis remain poorly understood. In this study we analyze the chromatin accesibility of DP3 minus cells and three human T-ALL leukemia.
Project description:The objectives of this study is to evaluate the chromatin accesibility changes after deoxyshikonin stimulation in porcine intestinal epithelial cells.
Project description:We identify a temporal cascade of ecdysone-inducible transcription factor gene expression during Drosophila wing development. This temporal cascade corresponds with dynamic changes in chromatin accesibility during wing development. We hypothesized that these temporally regulated transcription factors may coordinate these dynamic open chromatin changes. To test this, we investigate the ecdysone-inducible transcription factor, E93, which we determine is required for coordinating transitions in developmental stage by regulating chromatin accesibility of cis-regulatory elements.