Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Liver macrophages in YapS127A and wildtype livers

ABSTRACT: Liver macrophages in YapS127A and wildtype livers

PROVIDER: PRJNA526206 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Liver macrophages in YapS127A and wildtype livers

Project description:Disturbance of heterologous cell communication is associated with a structural reorganization of the vascular niche, a process called capillarization, which is already initiated in early stages of liver tumor development. In this study, the molecular characterization of endothelial cell (EC) subpopulations from healthy livers and yes-associated protein (Yap)-induced liver tumors revealed a dynamic crosstalk between liver sinusoidal endothelial cells (LSECs) and capillary endothelial cells (CECs). Initial paracrine stimuli from parenchymal cells include the Yap/Tead4 target gene osteopontin (Opn), which promotes CECs expansion through the induction of c-Met and sensitization towards LSEC-derived hepatocyte growth factor (Hgf). In addition, Yap/Tead4-induced C-C motif chemokine ligand 2 (Ccl2) recruits bone-marrow-derived macrophages (BMDMs) with an unpolarized phenotype (M0) to the perivascular space of expanding CECs.

2020-09-15 | GSE128045 | GEO

Expression data from livers in wildtype and Sox17+/-mice at 17dpc

2013-01-09 | GSE33106 | GEO

Expression data from livers in wildtype and Sox17+/-mice at 17dpc

Project description:The onset of the liver inflamentation in the Sox17+/- embryos. The expression of Cxcl10, Cxcl2, Cxcl1 and stress-induced heat shock protein Hspa1a and Hspa1b were elevated in Sox17+/- livers at 17dpc, as compared with the wildtype livers. Total RNAs from liver tissues of wildtype and Sox17+/- mice at 17dpc were subjected to microarray analyses. Two biological replicates of each genotype were analyzed.

2013-01-09 | E-GEOD-33106 | biostudies-arrayexpress

Wildtype and NRP1 knockout macrophages

Project description:Wildtype and NRP1 knockout macrophages

| PRJNA433729 | ENA

Proteomic analysis of mouse liver with conditional knock-out of Cathepsin D in macrophages

Project description:The cell-specific role of lysosomal protease cathepsin D (CtsD) in liver fibrosis is not completely clear. This study reports that while CtsD is highly expressed in liver macrophages of cirrhotic patients, CtsD deletion in macrophages resulted in enhanced liver fibrosis. For this scope, a macrophage-CtsD knock-out mouse (CtsDMac) model was generated. Livers obtained from the mouse model and from its control were analyzed by shotgun label-free quantitative (LFQ) proteomics.

2024-07-25 | PXD032827 | Pride

Characterization of macrophages in healthy and diseased livers in mice

Project description:Healthy livers contain many resident macrophages named Kupffer cells (KCs), which are partially replaced by infiltrating monocyte-derived macrophages (MoMFs) during acute or chronic liver injury. Despite extensive research, understanding macrophage heterogeneity, spatial distribution, and interactions with other cells within the liver remains challenging. We performed single-cell RNA sequencing to investigate liver macrophage gene expression in naïve and Concanavalin A (ConA)-treated mice. MoMF clusters expanded following ConA treatment, while KCs remained stable. Macrophages were divided into distinct subtypes, including C1q+ MoMFs, with differential expression of genes like Trem2, Spp1, Fabp5 and Gpnmb. Newly recruited C1q- MoMFs expressed high levels of Lyz and Ccr2, while Itgax (Cd11c)+ MoMFs expressed endothelin converting enzyme 1 (Ece1), a gene encoding ECE1 enzyme that activates endothelin to promote hepatic stellate cell contraction and necrotic lesion resolution. By immunostaining analysis of the proteins encoded by these signature genes, we identified several populations of MoMFs that were mainly located surrounding the necrotic lesion area and expressed various proteins that are involved dead cell debris clearance.

2025-03-01 | GSE287737 | GEO

Mouse Liver: Tumors vs livers with transgene turned off for 4 weeks vs livers with transgene turned off for 12 weeks vs Normal

Project description:Transcriptional Profiling of mouse liver tissues comparing normal tissues, livers arising from transgene expression after hepatocy transplantation using the comparative hepatocyte growth assay, and livers with transgene turned off for 4 and 12 weeks. Experimental groups: Control normal liver; Endstage liver tumors, livers with transgene turned off for 4 weeks, and livers with transgene turned off for 12 weeks.

2014-07-15 | GSE59211 | GEO

Expression data of resident macrophages from the livers of wildtype mice and Melanocortin 4 receptor-deficient (MC4R-KO) mice with non alcoholic steatohepatitis (NASH)

Project description:There is a unique histological structure termed hepatic crown-like structure (hCLS), in which CD11c-positive macrophages surround dead or dying hepatocytes with large lipid droplets in NASH livers. To characterize gene expression patterns, we performed microarray analysis using hepatic resident macrophages. CD11c-positive macrophages exhibited distinct polarization profiles from typical M1 and M2 macrophages, and there were clear differences in the gene expression profiles from CD11c-negative macrophages.

2018-01-01 | GSE104901 | GEO

Expression data from wildtype and Rb-/- fetal liver at e12.5

Project description:Rb null embryos exhibit defective fetal liver erythropoiesis. We used microarrays to compare Wt and Rb null fetal livers and to analyse gene expression differences which accompany and may underlie Rb null fetal liver degeneration, erythroid failure, and erythropoietic island dissolution. We used microarrays to compare Wt and Rb null fetal livers and analyse gene expression changes which accompany and may underlie fetal liver. Keywords: retinoblastoma, fetal liver, erythroblast, macrophage, cell death

2007-06-05 | GSE6787 | GEO

MAGL deficiency in liver macrophages

Project description:MAGL deficiency in liver macrophages

| PRJNA781292 | ENA