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Expression data from splenic IL-10 positive and IL-10 negative B cells of C57BL/6

ABSTRACT: Expression data from splenic IL-10 positive and IL-10 negative B cells of C57BL/6

PROVIDER: PRJNA530683 | ENA |

REPOSITORIES: ENA

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Expression data from splenic IL-10 positive and IL-10 negative B cells of C57BL/6

Project description:The mechanisms in regulating the development of IL-10 producing B cells are largely unknown. To clarify which transcription factor is critical for regulation of IL-10 producing B cells, we compared the gene expression profile of IL-10 positive B cells and IL-10 negative B cells. Transcriptional repressor Prdm1/Blimp1 is known to play a key role in controlling B ells differentiation. We show a dual role for Blimp-1 in IL-10 expression in IL-10 producing B cells and plasmablasts.

2019-09-11 | GSE129260 | GEO

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Project description:Gene expression analysis of murine splenic IL-10+ and IL-10- B cells

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ATAC-seq examining chromatin accessibility of mouse splenic IL-10+ and IL-10-CD19+CD21hiCD24hi B cells

Project description:Chromatin profiling of mouse splenic ex-vivo IL-10+, IL-10-CD19+CD21hiCD23hiCD24hi B cells and IL-10- follicular B cells, after antigen induced arthritis. IL-10eGFP reporter (Vert-X) mice were used to sort IL-10+ and IL-10- subsets. ATAC-seq was used in conjunction with microarray data to understand the chromatin profiles and transcriptional landscape of mouse regulatory B cells, compared to other B cell subsets.

2019-10-09 | E-MTAB-8393 | biostudies-arrayexpress

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Project description:IL-10

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VDJ analysis of IL-10+ and IL-10- splenic B1a, MZ, and FO B cells from sIgM-/- mouse

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VDJ analysis of IL-10+ and IL-10- splenic B1a, MZ, and FO B cells from sIgM-/- mouse

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Gene expression analysis of murine splenic IL-10+ and IL-10- B cells

Project description:B cells belong to the adaptive immune system and have multiple functions. Besides their well characterized role in the promotion of the immune response, specific B cell subsets were shown to have an anti-inflammatory function. These cells are termed regulatory B cells and they exert their function mainly through the production of interleukin 10 (IL-10). This study focuses on B cells capable of producing IL-10 after 5 hours of stimulation with LPS, PMA and ionomycin, without any distinction based on surface markers.

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Effect of IL-12+IL-18 or anti-NK1.1 stimulation on splenic NK cells [mNK_Activation_RNA-seq]

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Genome-wide maps of Runx3 bound regions in splenic IL-2-activated CD8+ T cells

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