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ABSTRACT: RNA-seq of peripheral blood cells from heart failure patients

PROVIDER: PRJNA532278 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8882910_1.fastq.gz	Fastqsanger.gz
	SRR8882910_2.fastq.gz	Fastqsanger.gz
	SRR8882920_1.fastq.gz	Fastqsanger.gz
	SRR8882920_2.fastq.gz	Fastqsanger.gz
	SRR8882911_1.fastq.gz	Fastqsanger.gz

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Heart failure patients' peripheral blood mononuclear cell gene expression profiles before mechanical circulatory support

Project description:This data represents whole transcriptome total RNA gene expression profiles of peripheral blood mononuclear cells collected from 29 advanced heart failure patients on the day before undergoing mechanical circulatory support surgery. Keywords = Advanced Heart Failure. Keywords = Mechanical Circulatory Support. Keywords = Biological Age. Keywords = PBMC. Keywords = Immune Response. Keywords = Peripheral Blood. Keywords =Organ Function. Keywords = Recovery. Organism: Homo sapiens. Type: Expression profiling by array. Platforms: Illumina HiSeq 2500.

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Circulating microRNAs are candidate markers of heart failure and differentiate between heart failure with reduced vs preserved left ventricular ejection fraction.

Project description:In this study, we compared the expression profiles of circulating miRNAs in blood samples from controls and patients with heart ailment. Subject with no past history of heart failure/disease are considered as controls. The patients were classified according to the percentage of left ventricular ejection fraction. Patients were grouped as heart failure with reduced (hfREF) and preserved (hfPEF) left ventricular ejection fraction. Employing miRNA microarray, we identified 'signature miRNAs' in peripheral blood samples that distinguished Heart failure from the non-heart failure controls, as well as those of hfREF and hfPEF groups.

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Project description:Two matched groups of Heart Failure with reduced ejection fraction patients with no peripheral venous congestion were studied: with recent prior heart failure hospitalization vs. without recent heart failure hospitalization. Peripheral venous congestion was modeled by inflating a cuff around the dominant arm, targeting an ~30mmHg increase in venous pressure (venous stress test). Blood and endothelial cells were sampled before and after 90 minutes of venous stress test.

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Project description:Human white blood cells from healthy, heart failure risk patients, asymptomatic left ventricular dysfunction patients, chronic heart failure, acute heart failure patients Common reference experiment, 9 replicates per group.

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Heart failure patients' peripheral blood mononuclear cell gene expression profiles before mechanical circulatory support

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