Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional profiling of human white blood cells at the different stages of NYHA classification


ABSTRACT: Human white blood cells from healthy, heart failure risk patients, asymptomatic left ventricular dysfunction patients, chronic heart failure, acute heart failure patients Common reference experiment, 9 replicates per group.

ORGANISM(S): Homo sapiens

SUBMITTER: Philippe Rouet 

PROVIDER: E-GEOD-21125 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>The preclinical stage of systolic heart failure (HF), known as asymptomatic left ventricular dysfunction (ALVD), is diagnosed only by echocardiography, frequent in the general population and leads to a high risk of developing severe HF. Large scale screening for ALVD is a difficult task and represents a major unmet clinical challenge that requires the determination of ALVD biomarkers.<h4>Methodology/principal findings</h4>294 individuals were screened by echocardiography. We i  ...[more]

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