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Single-cell transcriptomic map of the human and mouse bladders

ABSTRACT: Single-cell transcriptomic map of the human and mouse bladders

PROVIDER: PRJNA532936 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8903510.fastq.gz	Fastqsanger.gz
	SRR8903511.fastq.gz	Fastqsanger.gz
	SRR8903512.fastq.gz	Fastqsanger.gz
	SRR8903513.fastq.gz	Fastqsanger.gz
	SRR8903514.fastq.gz	Fastqsanger.gz

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Single-cell transcriptomic map of the human and mouse bladders

Project description:A comprehensive cellular anatomy of normal human bladder is vital to address the cellular origins of benign bladder disease and bladder cancer. The physiological function and pathological changes of bladder are associated with its cell type. To investigate the classification and underlying function of bladder cells, we conducted single-cell RNA sequencing (scRNA seq) of 12,423 cells from human bladder and 12,884 cells from mouse bladder. Here, we show a single-cell transcriptomic map of the human and mouse bladders, including 16 clusters of human bladder cells and 15 clusters of mouse bladder cells. Homology and heterogeneity of human and mouse were compared and analyzed by our study, and indicated that there were both conservative and heterogeneous aspects of human and mouse evolution. We also discovered two novel types of human bladder cells; one type is ADRA2A+ and HRH2+ interstitial cells which may be associated with nerve conduction and allergic reactions; the other type is TNNT1+ epithelial cells that may be different from other epithelial cells in biological function. Collectively, this analysis provides a resource for the discovery of novel cell type, specific transcription factors, signaling receptors, and genes dataset that will help us to study the relationship between cell types and diseases.

2019-08-28 | GSE129845 | GEO

Single-Cell Transcriptomic Map of the Human and Mouse Bladders.

Project description:BackgroundHaving a comprehensive map of the cellular anatomy of the normal human bladder is vital to understanding the cellular origins of benign bladder disease and bladder cancer.MethodsWe used single-cell RNA sequencing (scRNA-seq) of 12,423 cells from healthy human bladder tissue samples taken from patients with bladder cancer and 12,884 cells from mouse bladders to classify bladder cell types and their underlying functions.ResultsWe created a single-cell transcriptomic map of human and mouse bladders, including 16 clusters of human bladder cells and 15 clusters of mouse bladder cells. The homology and heterogeneity of human and mouse bladder cell types were compared and both conservative and heterogeneous aspects of human and mouse bladder evolution were identified. We also discovered two novel types of human bladder cells. One type is ADRA2A + and HRH2 + interstitial cells which may be associated with nerve conduction and allergic reactions. The other type is TNNT1 + epithelial cells that may be involved with bladder emptying. We verify these TNNT1 + epithelial cells also occur in rat and mouse bladders.ConclusionsThis transcriptomic map provides a resource for studying bladder cell types, specific cell markers, signaling receptors, and genes that will help us to learn more about the relationship between bladder cell types and diseases.

| S-EPMC6830796 | biostudies-literature

Single-cell transcriptomic mapping of immune cells in mouse bladders during urinary tract infection

Project description:Single-cell transcriptomic mapping of immune cells in mouse bladders during urinary tract infection

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Single-cell transcriptomic mapping of immune cells in mouse bladders during urinary tract infection

Project description:To explore the classification and functional roles of bladder immune cells during urinary tract infection (UTI), we performed scRNA-seq analysis of immune cells extracted from mouse bladders.

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Young and aged mouse bladders

Project description:Young and aged mouse bladders

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Gene expression of unperturbed young and aged mouse bladders

Project description:Aging has multifaceted effects on the immune system, but how aging affects tissue-specific immunity is not well-defined. Bladder diseases characterized by chronic inflammation are highly prevalent in older women, but mechanisms by which aging promotes these pathologies remain unknown. Tissue transcriptomics of unperturbed, young, and aged bladders identified a highly altered immune landscape as a fundamental feature of the aging female bladder. Detailed mapping of immune cells using single cell RNA- sequencing revealed novel subsets of macrophages and dendritic cells and unique changes to the immune repertoire in the aged bladder. B and T cells are highly enriched in aged bladders and spontaneously form organized bladder tertiary lymphoid tissues (bTLTs).

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scRNAseq of immune cells from young and aged mouse bladders

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Gene expression of unperturbed young and aged mouse bladders

Project description:Gene expression of unperturbed young and aged mouse bladders

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IL22RKO bladders following UTI

Project description:WT or IL22RKO mice recived a UTI and bladders were collected for RNAseq

2022-06-25 | GSE174735 | GEO

IL22RKO bladders following UTI

Project description:IL22RKO bladders following UTI

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