Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Next Generation Sequencing to identify the gene expression profile of cardiosphere-derived cells (CDCs) and c-kitpos cardiac progenitor (c-kitpos CPC) cells derived from adult and young donors

ABSTRACT: Next Generation Sequencing to identify the gene expression profile of cardiosphere-derived cells (CDCs) and c-kitpos cardiac progenitor (c-kitpos CPC) cells derived from adult and young donors

PROVIDER: PRJNA534229 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8944400.fastq.gz	Fastqsanger.gz
	SRR8944410.fastq.gz	Fastqsanger.gz
	SRR8944420.fastq.gz	Fastqsanger.gz
	SRR8944430.fastq.gz	Fastqsanger.gz
	SRR8944440.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 80

Similar Datasets

Extracellular vesicles (EV) from IFNγ-primed cardiosphere-derived cells (CDCs)

Project description:Characterization of proteins in extracellular vesicles (EV) from cardiosphere-derived cells (CDCs) of a clinically relevant pig model. Additionally, considering that priming stem cells with inflammatory stimuli may increase the therapeutic potential of released vesicles, here we studied the dynamic changes that take place in the EV from IFNγ-primed CDCs.

2020-05-15 | PXD016434 | Pride

Next Generation Sequencing to identify the gene expression profile of cardiosphere-derived cells (CDCs) and c-kitpos cardiac progenitor (c-kitpos CPC) cells derived from adult and young donors

Project description:In this study we therefore focused on 2 heart-derived progenitor cell populations that have been recently introduced in clinical translation, autologous c-kitpos–selected CPCs and CDCs. For the first time we compared molecular signatures and proliferation and differentiation characteristics of progenitor cells from young donor hearts (c-kitpos yCPC and yCDC) with cells obtained from adult donors with advanced ischemic disease (c-kitpos aCPC and aCDC). Here we report that culture expanded CDCs derived from adult donors have a distinct transcriptional profile with greater cell cycle activity and superior in vitro paracrine growth factor release compared to yCDCs. The molecular signature of aduIt CDCs favours cardiac repair via pro-angiogenic, cytotrophic and immunomodulatory effects while cardiac transdifferentiation potential is modest and comparable in all progenitor cell populations.

2022-04-22 | GSE130179 | GEO

comparison of primary epicardium explant derived CDCs and primary Epicardial cells

Project description:The analysis showed differences of transcriptomes between primary epicardium explant derived CDCs and primary Epicardial cells directly isolated from the heart epicardium.SB-431542 was an effective TGF-b pathway inhibitor that could obviously inhibit the epicardial cells Epithelial-mesenchymal transition. SB-432542 treatment could produce some epithelial clones in the CDCs,which showed epicardiac specific expression profile, compared with the CDCs.

2022-02-18 | GSE189275 | GEO

Transcriptome analysis of mdx hearts and skeletal muscles treated with cardiac progenitor cells and their exosomes

Project description:Aged mdx mice were treated with 2.5x105 cardiosphere-derived cells (CDCs) or 2.0x109 exosomes intravenously. Hearts and skeletal muscles were harvested 3 weeks post-treatment and prepared for RNA sequencing.

2019-05-17 | GSE124068 | GEO

Single Cell RNA Sequencing of Cultured Primary Tissue Cells.

Project description:Using a single cell-RNA sequencing protocol from 10xGenomics, we compared so called cardiosphere-derived cells (CDCs, established protocol) to the main non-myocyte cell types of the adult heart: cardiac fibroblasts (CFs), smooth muscle cells (SMCs) and endothelial cells (ECs). Herby, CDCs were disclosed as a heterogenic cell type with clear similarities to cardiac non-myocyte cell types, particularly to CFs and SMCs. Beyond a high proliferation capacity and upregulation of immune-related genes, CDCs exhibited a strong extracellular matrix synthesizing ability and also some angiogenic potential. Subsequently, infant patient derived CDCs were compared to adult CDCs, revealing that infant-CDC upregulated developmental and angiogenic processes. This study represents the first characterization of CDCs by sc-RNAseq and unravels their age-dependent molecular differences.

2021-09-27 | GSE149699 | GEO

comparison of primary epicardium explant derived CDCs and primary Epicardial cells

Project description:comparison of primary epicardium explant derived CDCs and primary Epicardial cells

| PRJNA782323 | ENA

Hyperphosphorylation of sarcomeric proteins in heart failure with preserved ejection fraction: selective reversal of PKC hyperactivity by cell therapy

Project description:Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, cardiac stiffness, Ca2+-sensitivity and mechanosensing. Treatment with cardiosphere-derived cells (CDCs) restores normal diastolic function, attenuates fibrosis and inflammation, and improves survival in a rat HFpEF model. Here, we quantified the phosphorylation changes that underlie HFpEF and those reversed by CDC therapy, with a focus on the sarcomeric subproteome.

2022-04-23 | PXD025555 | Pride

Phyllosticta sp. CPC 27913 isolate:CPC 27913

Project description:Phyllosticta sp. CPC 27913 Transcriptome - RNAPhylcitrieu4

| PRJNA411557 | ENA

Phyllosticta sp. CPC 27913 isolate:CPC 27913

Project description:Phyllosticta sp. CPC 27913 Standard Draft genome sequencing

| PRJNA331295 | ENA

Phyllosticta citribraziliensis strain:CPC 17464

Project description:Phyllosticta citribraziliensis CPC 17464 Transcriptome

| PRJNA712125 | ENA