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Transcriptome profiling of prostate cancer cells on GLYATL1 knockdown

ABSTRACT: Transcriptome profiling of prostate cancer cells on GLYATL1 knockdown

PROVIDER: PRJNA539980 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8980030_1.fastq.gz	Fastqsanger.gz
	SRR8980030_2.fastq.gz	Fastqsanger.gz
	SRR8980031_1.fastq.gz	Fastqsanger.gz
	SRR8980031_2.fastq.gz	Fastqsanger.gz
	SRR8980028_1.fastq.gz	Fastqsanger.gz

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Transcriptome profiling of prostate cancer cells on GLYATL1 knockdown

Project description:The protein Glycine-N-Acyltransferase Like 1 (GLYATL1) is involved in detoxification of benzoate and other xenobiotics and is expressed in liver and kidney. Through In silico analysis of cancer gene expression profiling and transcriptome sequencing we revealed an overexpression of GLYATL1 in primary prostate cancer. Confirming these findings by immunohistochemistry we show that GLYATL1 is overexpressed in primary prostate cancer compared to metastatic prostate cancer and benign prostatic tissue. Low grade cancers had higher GLYATL1 expression compared to high grade prostate tumors. Our studies showed that GLYATL1 is upregulated upon androgen treatment in LNCaP prostate cancer cells which harbors ETV1 gene rearrangement. Furthermore, ETV1 knockdown in LNCaP cells showed downregulation of GLYATL1 suggesting potential regulation of GLYATL1 by ETS transcription factor ETV1. Transcriptome sequencing using the GLYATL1 knockdown prostate cancer cell lines LNCaP showed regulation of multiple metabolic pathways. In summary, our study characterizes the expression GLYATL1 in prostate cancer and explore its regulation mechanism. Future studies are needed to decipher the biological significance of these findings.

2019-12-17 | GSE130395 | GEO

Gene expression profiling of prostate cancer cells upon JMJD2A or ETV1 knockdown

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Gene expression profiling of prostate cancer cells upon JMJD2A or ETV1 knockdown

Project description:Gene expression profiling of LNCaP prostate cancer cells that have JMJD2A knockdown (JMJD2A shRNA #3; JMJD2A shRNA #5) or ETV knockdown (ETV shRNA #1; ETC shRNA #5) were compared to non-targeted control (sh-cm) cells. Total RNA was isolated from transformed LNCaP human prostate cancer cells containing a non-trageting control vector (sh-cm), vectors containing shRNA sequences for JMJD2A or ETV1 genes.

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Project description:Identifying the effect of the co-chaperone SGTA on global androgen receptor transcriptional activity in C4-2B prostate cancer cells with view to further elucidating the broader biological role of SGTA on other signaling pathways within prostate cancer cells Knockdown of SGTA for 72 hours in C4-2B cells significantly altered the expression of approximately 1900 genes in both vehicle and DHT treated cells. The effect of SGTA knockdown was to suppress the expression of approximately 60% of those transcripts. The regulation of 35% of DHT target genes was also affected by SGTA knockdown, with gene-specific effects on basal, or DHT-induced expression, or both.

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Project description:PRMT5 knockdown changes gene expression in prostate cancer cells

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RNA-seq of METTL3 knockdown in prostate cancer cells

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