Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Determinaton the effect of IR-61 on macrophage gene expression

ABSTRACT: Determinaton the effect of IR-61 on macrophage gene expression

PROVIDER: PRJNA541134 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Determinaton the effect of IR-61 on macrophage gene expression

Project description:To identify the influence of IR-61 on macrophage gene expression , we have employed whole genome microarray expression profiling as a discovery platform to identify genes expression changes. RAW264.7 cell line was treated with additional 10μm IR-61 or vehicle control for 24 h and then conducted further experiments

2019-05-06 | GSE130718 | GEO

Effect of TET3 expression in macrophage

Project description:Effect of TET3 expression in macrophage

| PRJNA924837 | ENA

61 lymphoma cell lines gene expression profiles

Project description:assess the gene expression profiling of 61 cell lines

2018-02-09 | GSE94669 | GEO

Gene expression signatures of megakaryocytes post-IR

Project description:Platelets are anucleated blood cells that are produced by their progenitor cell, the megakaryocyte (MK). Platelets are centrally positioned in hemostasis and thrombosis and, according to the recent findings, play key roles in innate immunity, inflammation, atherogenesis, and cancer metastasis. The quantitative and qualitative properties of platelets are crucial determinants of their hemostatic function. While the regulatory mechanisms of platelet number and size have been studied separately, critical questions remain regarding the interplay of platelet number and size in hemostasis. In this study, using a mouse model of irradiation (IR)-induced thrombocytopenia, we show that mature MKs (mMKs) are resistant to IR and maintain the nadir platelet levels post IR. To identify the phenotype switching and function variation in BM MKs post IR, we performed microarray expression profiling of MKs from the bone marrow of mice at 1- or 3-days post IR and control mice (Ctrl).

2023-12-27 | GSE222512 | GEO

The effect of the Rocaglate on the macrophage gene expression

Project description:The effect of the Rocaglate on the macrophage gene expression

| PRJNA449947 | ENA

Streptomyces sp. 61 strain:61

Project description:Streptomyces sp. 61 strain:61 Genome sequencing

| PRJNA403471 | ENA

Gene expression profiling of IR-/-, IGF-1R-/- (dKO) newborn epidermis.

Project description:Analysis of newborn mouse epidermis lacking the expression of Insulin receptor (IR) and Insulin like growth factor 1 receptor (IGF-1R). Results show that IR/IGF-1R signalling control epidermal morphogenesis.

2013-05-18 | GSE47065 | GEO

Janthinobacterium sp. 61 strain:61

Project description:Janthinobacterium sp. 61 strain:61 Genome sequencing and assembly

| PRJNA402414 | ENA

Gene expression, methylome and splicing of THP-1 monocytic cells and THP-1-derived macrophage

Project description:Monocytes and macrophages are essential components of the innate immune system. Herein, we report that intron retention (IR) plays an important role in the development and function of these cells. Using mRNA sequencing, bioinformatics analyses and RT-qPCR validation, we identified differential IR and altered expression of key genes involved in macrophage development and function, both in vitro and in vivo. We demonstrate that decreased IR in nuclear-detained mRNA is coupled to increased expression of genes encoding regulators of macrophage transcription, phagocytosis and inflammatory signalling, including ID2, IRF7, ENG and LAT. We further show that this dynamic IR program persists during the polarisation of resting macrophages into activated macrophages. In the presence of proinflammatory stimuli, intron-retaining CXCL2 and NFKBIZ transcripts in macrophages are rapidly spliced, leading to timely expression of these key inflammatory regulators by macrophages. Our study provides novel insights into the molecular mechanisms controlling vital regulators of the innate immune response.

2019-04-19 | GSE130011 | GEO

MiRNA Expression data from Tk6 cell treated with arsenic, gamma-IR, or grown under folate-deficiency

Project description:Folate deficiency, arsenic exposure, and gamma-IR are known developmental toxicants and have carcinogenic effects. The mechanism by which IR is known, but the effect of arsenic or folate deficiency remains unclear. Their effect may be mediated by epigenetic alterations, leading to miRNA expression changes, and this experiment examined this hypothesis We used microarrays to detail the miRNA expression profiles of TK6 cells treated with 2 uM sodium arsenite for 6 days, folate-deficient media for 6 days, or 2.5 Gy IR exposure either acutely at 4 hours post exposure or long-term at 6 days post exposure, as well as requiste controls, all in biological triplicate. Keywords: exposure differences

2006-11-15 | GSE6020 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data