Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tramtrack safeguards tissue identity of Drosophila intestinal stem cells by preventing neuroblast-like program activation and neuroendocrine tumors

ABSTRACT: Tramtrack safeguards tissue identity of Drosophila intestinal stem cells by preventing neuroblast-like program activation and neuroendocrine tumors

PROVIDER: PRJNA542061 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9032290.fastq.gz	Fastqsanger.gz
	SRR9032680.fastq.gz	Fastqsanger.gz
	SRR9032690.fastq.gz	Fastqsanger.gz
	SRR9032291.fastq.gz	Fastqsanger.gz
	SRR9032681.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 27

Similar Datasets

Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

Project description:Integration of spatial and temporal identity during Drosophila neurogenesis is due to spatial factors generating neuroblast-specific chromatin thereby biasing subsequent temporal transcription factor binding and producing neuroblast-specific neurons.

2019-01-25 | GSE123272 | GEO

Tramtrack safeguards tissue identity of Drosophila intestinal stem cells by preventing neuroblast-like program activation and neuroendocrine tumors

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-23 | GSE130943 | GEO

Epigenetic safeguards are coordinately removed to reverse cell identity

Project description:Epigenetic safeguards are coordinately removed to reverse cell identity

| PRJNA488060 | ENA

TRIM28 establishes skeletal stem cell identity and safeguards skeletogenesis

Project description:TRIM28 establishes skeletal stem cell identity and safeguards skeletogenesis

| PRJNA834101 | ENA

TRIM28 establishes skeletal stem cell identity and safeguards skeletogenesis (WGBS)

Project description:TRIM28 establishes skeletal stem cell identity and safeguards skeletogenesis (WGBS)

| PRJNA834104 | ENA

PCAT19 safeguards quiescent endothelial DNA by preventing uncontrolled phosphorylation of replication protein A2

Project description:PCAT19 safeguards quiescent endothelial DNA by preventing uncontrolled phosphorylation of replication protein A2

| PRJNA818329 | ENA

Chromatin remodeler Brahma safeguards labile canalization of cardiac mesoderm differentiation

Project description:Differentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization. Canalization is essential for stabilizing cell fate, but mechanisms underlying robust canalization are unclear. Here we show that the BRG1/BRM-associated factor (BAF) chromatin remodeling complex ATPase gene Brm safeguards cell identity during directed cardiogenesis of mouse embryonic stem cells. Despite establishment of well-differentiated precardiac mesoderm, Brm-null cells predominantly became neural precursors, violating germ layer assignment. Trajectory inference showed sudden acquisition of non-mesodermal identity in Brm-null cells, consistent with a new transition state referred to as a saddle-node bifurcation. Mechanistically, loss of Brm prevented de novo accessibility of cardiac enhancers while increasing expression of neurogenic factor POU3F1, preventing expression of neural suppressor REST, and disrupting composition of BRG1 complexes. Brm mutant identity switch was overcome by increasing BMP4 levels during mesoderm induction. Mathematical modeling supports all our observations. In the mouse embryo, Brm deletion exacerbated mesoderm-deleted Brg1 mutant phenotypes, severely compromising cardiogenesis, unmasking an in vivo role for Brm. Our results reveal Brm as a compensable safeguard of the fidelity of mesoderm chromatin states, and support a model in which developmental canalization is not a rigid irreversible path, but a highly plastic trajectory.

2021-11-03 | PXD026638 | Pride

Epigenetic safeguards are coordinately removed to reverse cell identity [5hmC Enrichment]

Project description:Epigenetic safeguards are coordinately removed to reverse cell identity [5hmC Enrichment]

| PRJNA488064 | ENA

TRIM28 establishes skeletal stem cell identity and safeguards skeletogenesis (ChIP-Seq)

Project description:TRIM28 establishes skeletal stem cell identity and safeguards skeletogenesis (ChIP-Seq)

| PRJNA834108 | ENA

Epigenetic safeguards are coordinately removed to reverse cell identity [RNA-Seq]

Project description:Epigenetic safeguards are coordinately removed to reverse cell identity [RNA-Seq]

| PRJNA488063 | ENA