Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Functional characterization of the Differences Between Parotid and Submandibular Salivary Glands

ABSTRACT: Functional characterization of the Differences Between Parotid and Submandibular Salivary Glands

PROVIDER: PRJNA543115 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9062600.fastq.gz	Fastqsanger.gz
	SRR9062601.fastq.gz	Fastqsanger.gz
	SRR9062602.fastq.gz	Fastqsanger.gz
	SRR9062603.fastq.gz	Fastqsanger.gz
	SRR9062604.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 7

Similar Datasets

Functional characterization of the Differences Between Parotid and Submandibular Salivary Glands

Project description:We applied both single cell and bulk RNA-sequencing to characterize and identify uniqueness in gene expression of the mouse Parotid gland compared to other tissues including the submandibular gland

2019-10-07 | GSE131285 | GEO

Three Major salivary glands

Project description:The aim of this study is characterize the gene expression of rat parotid, submandibular and sublingual glands, providing basic information for the salivary marker proteins.

2010-05-15 | GSE21843 | GEO

Male/Female BALB/c Mouse Submandibular/Sublingual/Parotid/Lacrimal/Meibomian Glands

Project description:Series includes pooled (n = 5 mice per biological replicate) samples from submandibular, sublingual, parotid, lacrimal, and meibomian glands of BALB/c mice. Both male and female samples were analyzed on CodeLink Mouse Uniset I Microarrays. Keywords: repeat sample

2004-11-24 | GSE1503 | GEO

Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Bulk RNA-seq]

Project description:Our single-cell and bulk transcriptome analyses revealed striking molecular heterogeneity in the mesenchymal cells of embryonic submandibular and parotid salivary glands during bud initiation, including distinct mesodermal and neural crest-derived molecular signatures that foreshadow later functions.

2019-10-25 | GSE127260 | GEO

Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Single cell RNA-seq]

2019-10-25 | GSE127469 | GEO

Adult parotid gland RNA-seq libraries, and embryonic submandibular gland RNA-seq libraries

Project description:Adult parotid gland RNA-seq libraries and embryonic submandibular gland RNA-seq libraries were created to examine the mRNA species present in these secretory glands, as part of a project to understand acinar glands in general.

2017-08-18 | GSE102788 | GEO

Transcription profiling of submandibular salivary glands from mice congenic for the two chromosomal regions Nss1 and Idd5

Project description:Gene expression profiling and sialadenitis scoring in submandibular salivary glands from mice congenic for the two chromosomal regions Nss1 and Idd5.

2007-09-26 | E-BASE-6 | biostudies-arrayexpress

Mapping differences in salivary gland secretions using dried saliva spots

Project description:Dried saliva spot (DSS) sampling is a minimally invasive extraction technique that allows for the spatial mapping of salivary protein distribution in the oral cavity. In conjunction with untargeted nanoLC-Orbitrap-MS/MS analysis, we used DSS to compare the unstimulated proteomes secreted by the parotid and submandibular/sublingual salivary glands

2019-09-04 | PXD012792 | Pride

Integrative analysis of transcriptome and proteome sheds light on functional differences between human salivary glands

Project description:Saliva aids in the predigestion of food and perception of taste. It helps to maintain the integrity of the mineralized tooth and epithelial surfaces in the mouth, and shields the oro-digestive tract from environmental hazards and invading pathogens. Although salivary glands and saliva fluid are biologically and functionally inseparable, they have thus far been investigated as separate entities. To bridge this gap, we performed an integrative analysis of the transcriptome of 27 samples collected from the major human adult and fetal major salivary glands - submandibular, sublingual, and parotid - along with mass-spectrometry-based saliva proteome data and immunohistochemical localization in glandular tissue. Our results suggest that functional maturation at the transcriptome level occurs late in gland development, and is driven mainly by the transcription of genes that code for secreted saliva proteins. We further provide evidence that protein dosage of the most abundant salivary proteins secreted by the salivary glands is predominantly regulated at the transcriptome level. Finally, we demonstrate distinct transcriptomic profiles of each major salivary gland type that reveal functional specialization and will aid in future clinical analyses. Our study provides the hitherto most comprehensive RNAseq dataset of healthy salivary glands in humans, thus establishing a robust framework for deeper studies of saliva and salivary gland biology, development, and evolution, ultimately paving the way for better understanding the importance of these craniofacial secretory organs in health and their malfunctions in disease.

2020-07-10 | GSE143702 | GEO

Transcriptome Analysis of Rabies virus-infected Mice Salivary Glands

Project description:Rabies is a fatal zoonotic disease posing a threat to the public health globally. Rabies virus (RABV) is excreted in the saliva of infected animals, and is primarily transmitted through bite contact. Salivary glands play an important role for virus propagation. However, the significance of salivary glands is less studied in RABV pathogenic mechanisms. To identify functionally important genes in the salivary glands, we employed RNA sequencing (RNA-seq) to establish and analyze mRNA expression profiles in parotid tissue infected with two RABV strains, CVS-11 and PB4. We map the transcriptome changes in response to RABV infection in parotid tissue for the first time. This work provides new clues to the study of RABV-affected salivary gland function and RABV transmission mechanisms in parotid tissue. And the salivary gland-enriched transcripts could be potential targets of interest for rabies disease control.

2023-11-26 | GSE248365 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data