Project description:To investigate gene expression at different development stages of Agaricus blazei, we utilized Illumina Hiseq PE150 sequencing technology to obtain the transcriptome of mycelium and fruit body primodium
Project description:The edible mushroom Agaricus blazei Murill has immunomodulating and antiproliferative effects. In a clinical study 33 patients with multiple myeloma were randomized to receive treatment with Agaricus (16 patients) or placebo (17 patients) in addition to chemotherapy.
Project description:The effect on gene expression of an extract from a medicinal mushroom (Agaricus blazei Murill)were compared with the effect of lipopolysaccharides (LPS). Both are potent immunomodulators. The study used a monocyte cell line.
Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE) Two-condition experiment, E2- or ABE-treated vs. control cells. 2 to 3 biological replicates, independently grown and harvested. Two to three replicates per array.
Project description:The edible mushroom Agaricus blazei Murill has immunomodulating and antiproliferative effects. In a clinical study 33 patients with multiple myeloma were randomized to receive treatment with Agaricus (16 patients) or placebo (17 patients) in addition to chemotherapy. Gene expression profiles were analyzed before and after treatment in 8 patients in the agaricus group and in 6 patients in the control group and the differences were calculated